Fibrate Mechanism of Action - The Center for Cholesterol Management

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Fibrates and PPARα Agonism
Peroxisome Proliferorator-Activated Receptor α Peroxisome proliferator–activated receptor α (PPARα) is a ligand-activated nuclear receptor that regulates multiple genes involved with glucose and fatty acid metabolism, lipoprotein synthesis and catabolism, and vascular inflammation. Natural ligands include several fatty acids (saturated and unsaturated) and their derivatives, including eicosanoids. The PPARα/ligand complex requires heterodimerization with the retinoid X receptor/retinoic acid complex. After interaction with tissue-specific protein co-repressors or activators, the dimer attaches to distinct gene response elements, causing transcription of messenger RNA. Dayspring T & Pokrywka G Cur Athero Rep 2006, 8:356–364
Page 1: Understanding the Mechanism of Acti
Page 5 and 6: Role of Peroxisome Proliferator- Ac
Page 7 and 8: Peroxisome Proliferator-Activated R
Page 9 and 10: Fibrates Fibrates are weak agonist
Page 11 and 12: Fibrate Chemical Structure
Page 13 and 14: Fibrates Clofibrate , the prototyp
Page 15 and 16: Fenofibrate Tablet Pharmacokinetics
Page 17 and 18: Fenofibric Acid 2-[4-(4-Chlorobenzo
Page 19 and 20: Fibrate Effect on Lipids and Lipopr
Page 21 and 22: Fibrate Mechanisms of Action De
Page 23 and 24: Fatty Acid Transport Proteins In
Page 25 and 26: Fibrates and Triacylglycerol Synthe
Page 27 and 28: Effects of Micronized Fenofibrate o
Page 29 and 30: Fibrates and Triacylglycerol Synthe
Page 31 and 32: Fibrates and Triglyceride Synthesis
Page 33 and 34: Fibrate Mechanisms of Action Fibra
Page 35 and 36: Fenofibrate Indices LPL Expression
Page 37 and 38: Hepatocyte Removal of VLDL PPARα A
Page 39 and 40: Enhanced VLDL Lipolysis in Insulin
Page 41 and 42: Decreased CETP Mediated CE/TG Excha
Page 43 and 44: Fibrate Effect on Lipids and Lipopr
Page 45 and 46: Additional Generation of Pre-beta H
Page 47 and 48: Fibrates and Macrophage Reverse Cho
Page 49 and 50: Direct RCT at the Hepatocyte Hepato
Page 51 and 52: The VA High-Density Lipoprotein Cho
Page 53 and 54:
Fenofibrate Intervention and Event
Page 55 and 56:
Fibrates and HDL Remodeling Drug in
Page 57 and 58:
Fenofibrate Decreases Sterol Absorp
Page 59 and 60:
Fibrate Effect on Non Lipid Novel M
Page 61 and 62:
Anti-inflammatory and Immunomodulat
Page 63 and 64:
Anti-inflammatory and Immunomodulat
Page 65 and 66:
Fenofibrate & Adiponectin in Patien
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Fibrate Mechanism of Action - The Center for Cholesterol Management

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