Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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<strong>Fibrate</strong>s and HDL Remodeling<br />
Apo A-I production<br />
Decrease HDL-C<br />
Apo A-I gene<br />
expression<br />
SR-B1 gene<br />
expression<br />
ApoB Particle<br />
Smaller<br />
alpha HDL<br />
Apo A-II gene<br />
expression<br />
PPAR<br />
LXR<br />
ABC-1 gene<br />
expression<br />
CETP<br />
RXR<br />
Nascent<br />
or pre-β<br />
HDL<br />
Apo A-II<br />
production<br />
PPAR-α<br />
Agonism<br />
LXR<br />
Agonism<br />
Increase HDL-C<br />
ABCA-1<br />
production<br />
Maturing<br />
alpha HDL
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