Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Anti-inflammatory and<br />
Immunomodulatory Effects <strong>of</strong> PPARα<br />
Inflammatory response<br />
TNFα: tumor necrosis factor-α<br />
IFNγ: Interferon<br />
CRP: C-reactive protein<br />
COX-2: Cyclooxygenase-2 (affects prostaglandins)<br />
TF: Tissue factor in monocytes & macrophages<br />
Fibrinogen<br />
Lp-PLA 2 : Lp-associated Phospholipase A 2<br />
IL-1, IL-2, IL-6: Interleukins (affect VSMC activation)<br />
MMPs: Metalloproteinases in macrophages<br />
• PPARα activators inhibit<br />
multiple inflammatory<br />
cytokines produced by T-<br />
lymphocytes by preventing<br />
Th0 cells from differentiating<br />
to more deleterious Th1<br />
cells<br />
Marx N, et al. Circ Res.<br />
2002;90:703-710. & Circ Res.<br />
2004;94:1168-1178
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