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582 CHAPTER 11 REGRESSION ANALYSIS: SOME ADDITIONAL TECHNIQUES
22. A study by Davies et al. (A-17) was motivated by the fact that, in previous studies of contractile
responses to b-adrenoceptor agonists in single myocytes from failing and nonfailing human hearts,
they had observed an age-related decline in maximum response to isoproterenol, at frequencies
2 +
where the maximum response to high Ca in the same cell was unchanged. For the present study,
2 +
the investigators computed the isoproterenol/Ca ratio (ISO/CA) from measurements taken on
myocytes from patients ranging in age from 7 to 70 years. Subjects were classified as older ( 750
years) and younger. The following are the (ISO/CA) values, age, and myocyte source of subjects
in the study. Myocyte sources were reported as donor and biopsy.
Age ISO/CA Myocyte Source
7 1.37 Donor
21 1.39 Donor
28 1.17 Donor
35 0.71 Donor
38 1.14 Donor
50 0.95 Donor
51 0.86 Biopsy
52 0.72 Biopsy
55 0.53 Biopsy
56 0.81 Biopsy
61 0.86 Biopsy
70 0.77 Biopsy
Source: Dr. Sian E. Harding.
Used with permission.
23. Hayton et al. (A-18) investigated the pharmacokinetics and bioavailability of cefetamet and cefetamet
pivoxil in infants between the ages of 3.5 and 17.3 months who had received the antibiotic
during and after urological surgery. Among the pharmacokinetic data collected were the following
measurements of the steady-state apparent volume of distribution (V). Also shown are previously
collected data on children ages 3 to 12 years (A-19) and adults (A-20). Weights (W) of
subjects are also shown.
Infants Children Adults
W (kg) V (liters) W (kg) V (liters) W (kg) V (liters)
6.2 2.936 13 4.72 61 19.7
7.5 3.616 14 5.23 80 23.7
7.0 1.735 14 5.85 96 20.0
7.1 2.557 15 4.17 75 19.5
7.8 2.883 16 5.01 60 19.6
8.2 2.318 17 5.81 68 21.5
8.3 3.689 17 7.03 72.2 21.9
8.5 4.133 17.5 6.62 87 30.9
8.6 2.989 17 4.98 66.5 20.4
8.8 3.500 17.5 6.45
10.0 4.235 20 7.73
10.0 4.804 23 7.67
10.2 2.833 25 9.82
(Continued)