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470 CHAPTER 9 SIMPLE LINEAR REGRESSION AND CORRELATION
V LE V SE pH Range
4.6 5 .065
4.55 4.9 .056
4.4 4.6 .01
4.4 4.9 .058
4.2 4.4 .013
4.2 4.5 .03
Source: Anton Usaj, Ph.D.
Used with permission.
33. Bean et al. (A-22) conducted a study to assess the performance of the isoelectric focusing/
immunoblotting/laser densitometry (IEF/IB/LD) procedure to evaluate carbohydrate-deficient
transferrin (CDT) derived from dry blood spots. The investigators evaluated paired serum (S)
and dry blood spot (DBS) specimens simultaneously for CDT. Assessment of CDT serves as a
marker for alcohol abuse. The use of dry blood spots as a source of CDT for analysis by
IEF/IB/LD results in simplified sampling, storage, and transportation of specimens. The following
are the IEF/IB/LD values in densitometry units (DU) of CDT from 25 serum and dry blood
spot specimens:
Specimen No. S DBS Specimen No. S DBS
1 64 23 14 9 13
2 74 38 15 10 8
3 75 37 16 17 7
4 103 53 17 38 14
5 10 9 18 9 9
6 22 18 19 15 9
7 33 20 20 70 31
8 10 5 21 61 26
9 31 14 22 42 14
10 30 15 23 20 10
11 28 12 24 58 26
12 16 9 25 31 12
13 13 7
Source: Dr. Pamela Bean.
Used with permission.
34. Kato et al. (A-23) measured the plasma concentration of adrenomedullin (AM) in patients with
chronic congestive heart failure due to various cardiac diseases. AM is a hypotensive peptide,
which, on the basis of other studies, the authors say, has an implied role as a circulating hormone
in regulation of the cardiovascular system. Other data collected from the subjects included
plasma concentrations of hormones known to affect the cardiovascular system. Following are
the plasma AM (fmol/ml) and plasma renin activity (PRA) ( ng/L Á s) values for 19 heart failure
patients:
Patient Sex Age AM PRA
No. ( 1 M, 2 F) (Years) (fmol/ml) (ng/ L Á s)
1 1 70 12.11 .480594
2 1 44 7.306 .63894
3 1 72 6.906 1.219542
(Continued)