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REVIEW QUESTIONS AND EXERCISES 391
49. The purpose of a study by Maheux et al. (A-50) was to evaluate the effect of labor on glucose
production and glucose utilization. Subjects were six normal pregnant women. Among the data
collected were the following glucose concentrations during four stages of labor: latent (A1) and
active (A2) phases of cervical dilatation, fetal expulsion (B), and placental expulsion (C).
A1 A2 B C
3.60 4.40 5.30 6.20
3.53 3.70 4.10 3.80
4.02 4.80 5.40 5.27
4.90 5.33 6.30 6.20
4.06 4.65 6.10 6.90
3.97 5.20 4.90 4.60
Source: Dr. Pierre C. Maheux.
Used with permission.
50. Trachtman et al. (A-51) conducted studies (1) to assess the effect of recombinant human (rh) IGF-I on
chronic puromycin aminonucleoside (PAN) nephropathy and (2) to compare the results of rhIGF-I versus
rhGH treatment in a model of focal segmental glomerulosclerosis. As part of the studies, male
Sprague-Dawley rats were divided into four groups: PAN (IA), PAN + rhIGF-I (IB), normal (IIA),
and normal + rhIGF-I (IIB). The animals yielded the following data on creatinine levels before (pre)
and after 4, 8, and 12 weeks of treatment:
Group
IA IB IIA IIB
Pre
44 44 44 35
44 44 44 44
44 44 44 44
53 44 44 35
44 44
44 53
4 Weeks
97 44 53 44
88 35 44 53
62 44 44 53
53 35 53 44
62 62
53 53
8 Weeks
53 53 62 44
53 53 53 62
(Continued)