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REVIEW QUESTIONS AND EXERCISES 401
their research they used a bile-infusion model of acute pancreatitis to show amelioration of disease
severity as well as an improvement in overall survival by TNFa
inhibition. Experimental material
consisted of adult male Sprague-Dawley rats weighing between 250 and 300 grams divided into three
groups: untreated (bile solution infused without treatment); treated (bile solution infused preceded by
treatment with polyclonal anti-TNFa
antibody); and sham (saline infused). Among the data collected
were the following hematocrit (%) values for animals surviving more than 48 hours:
Sham Untreated Treated
38 56 40
40 60 42
32 50 38
36 50 46
40 50 36
40 35
38 40
40 40
38 55
40 35
36
40
40
35
45
Source: Dr. A. Osama Gaber. Used
with permission.
64. A study by Smárason et al. (A-65) was motivated by the observations of other researchers that sera
from pre-eclamptic women damaged cultured human endothelial cells. Subjects for the present study
were women with pre-eclampsia, matched control women with normal pregnancies, and nonpregnant
women of childbearing age. Among the data collected were the following observations on a
relevant variable measured on subjects in the three groups.
Pre-Eclampsia Pregnant Controls Nonpregnant Controls
113.5 91.4 94.5
106.6 95.6 115.9
39.1 113.1 107.2
95.5 100.8 103.2
43.5 88.2 104.7
49.2 92.2 94.9
99.5 78.6 93.0
102.9 96.9 100.4
101.2 91.6 107.1
104.9 108.6 105.5
75.4 77.3 119.3
71.1 100.0 88.2
73.9 61.7 82.2
(Continued)