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758 CHAPTER 13 NONPARAMETRIC AND DISTRIBUTION-FREE STATISTICS
Time (s) TF-IMT Time (s) TF-IMT
60% 10%
PI max
PI max
Week 0 Week 10 Week 0 Week 10
330 544 430 476
400 590 400 320
720 624 900 650
249 330 420 330
144 369 679 486
440 789 522 369
440 459 116 110
289 529 450 474
819 1099 570 700
540 930 199 259
Source: Dr. Yvonne F. Heijdra. Used with permission.
26. The three objectives of a study by Wolkin et al. (A-28) were to determine (a) the effects of chronic
haloperidol treatment on cerebral metabolism in schizophrenic patients, (b) the relation between
negative symptoms and haloperidol-induced regional changes in cerebral glucose utilization, and
(c) the relation between metabolic change and clinical antipsychotic effect. Subjects were 18 male
veterans’ hospital inpatients (10 black, five white, and three Hispanic) with either acute or chronic
decompensation of schizophrenia. Subjects ranged in age from 26 to 44 years, and their duration
of illness ranged from 7 to 27 years. Among the data collected were the following pretreatment
scores on the digit-symbol substitution subtest of the WAIS-R (DSY1RW) and haloperidol-induced
change in absolute left dorsolateral prefrontal cortex (DLLA3V1) and absolute right dorsolateral
prefrontal cortex (DLRA3V1) measured in units of mmol glucose/100 g tissue/min:
DSY1RW DLLA3V1 DLRA3V1 DSY1RW DLLA3V1 DLRA3V1
47 -7.97 -17.17 18 -4.91 -9.58
16 -8.08 -9.59 0 -1.71
.40
31 -10.15 -11.58 29 -4.62 -4.57
34 -5.46 -2.16 17 9.48 11.31
22 -17.12 -12.95 38 -6.59 -6.47
70 -12.12 -13.01 64 -12.19 -13.61
59 -9.70 -12.61 52 -15.13 -11.81
41 -9.02 -7.48 50 -10.82 -9.45
0 4.67 7.26 62 -4.92 -1.87
Source: Dr. Adam Wolkin. Used with permission.
27. The purpose of a study by Maltais et al. (A-29) was to compare and correlate the increase in arterial
lactic acid (La) during exercise and the oxidative capacity of the skeletal muscle in patients
with chronic obstructive pulmonary disease (COPD) and control subjects (C). There were nine
subjects in each group. The mean age of the patients was 62 years with a standard deviation of 5.
Control subjects had a mean age of 54 years with a standard deviation of 3. Among the data