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452 CHAPTER 9 SIMPLE LINEAR REGRESSION AND CORRELATION<br />

Age (Years) Bilirubin (mg/dl) Age (Years) Bilirubin (mg/dl)<br />

42 1.0 52 3.5<br />

58 5.2 58 5.6<br />

52 5.1 45 1.9<br />

Source: Geri R. Brown, M.D. Used with permission.<br />

9.7.2 Another variable of interest in the study by Reiss et al. (A-3) (see Exercise 9.3.4) was partial<br />

thromboplastin (aPTT), the standard test used to monitor heparin anticoagulation. Use the data in<br />

the following table to examine the correlation between aPTT levels as measured by the<br />

CoaguCheck point-of-care assay and standard laboratory hospital assay in 90 subjects receiving<br />

heparin alone, heparin with warfarin, and warfarin and exoenoxaparin.<br />

Warfarin and<br />

Heparin Warfarin Exoenoxaparin<br />

CoaguCheck Hospital CoaguCheck Hospital CoaguCheck Hospital<br />

aPTT aPTT aPTT aPTT aPTT aPTT<br />

49.3 71.4 18.0 77.0 56.5 46.5<br />

57.9 86.4 31.2 62.2 50.7 34.9<br />

59.0 75.6 58.7 53.2 37.3 28.0<br />

77.3 54.5 75.2 53.0 64.8 52.3<br />

42.3 57.7 18.0 45.7 41.2 37.5<br />

44.3 59.5 82.6 81.1 90.1 47.1<br />

90.0 77.2 29.6 40.9 23.1 27.1<br />

55.4 63.3 82.9 75.4 53.2 40.6<br />

20.3 27.6 58.7 55.7 27.3 37.8<br />

28.7 52.6 64.8 54.0 67.5 50.4<br />

64.3 101.6 37.9 79.4 33.6 34.2<br />

90.4 89.4 81.2 62.5 45.1 34.8<br />

64.3 66.2 18.0 36.5 56.2 44.2<br />

89.8 69.8 38.8 32.8 26.0 28.2<br />

74.7 91.3 95.4 68.9 67.8 46.3<br />

150.0 118.8 53.7 71.3 40.7 41.0<br />

32.4 30.9 128.3 111.1 36.2 35.7<br />

20.9 65.2 60.5 80.5 60.8 47.2<br />

89.5 77.9 150.0 150.0 30.2 39.7<br />

44.7 91.5 38.5 46.5 18.0 31.3<br />

61.0 90.5 58.9 89.1 55.6 53.0<br />

36.4 33.6 112.8 66.7 18.0 27.4<br />

52.9 88.0 26.7 29.5 18.0 35.7<br />

57.5 69.9 49.7 47.8 78.3 62.0<br />

39.1 41.0 85.6 63.3 75.3 36.7<br />

74.8 81.7 68.8 43.5 73.2 85.3<br />

32.5 33.3 18.0 54.0 42.0 38.3<br />

125.7 142.9 92.6 100.5 49.3 39.8<br />

77.1 98.2 46.2 52.4 22.8 42.3<br />

143.8 108.3 60.5 93.7 35.8 36.0<br />

Source: Curtis E. Haas, Pharm. D. Used with permission.

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