Disease staging: CliniCal anD CoDeD Criteria - HCUP

Cranial nerve palsy:
OR blindness in one or both eyes
OR loss of sense of smell
OR paralysis of one or both eye's musculature
OR facial numbness
OR facial paralysis
OR deafness in any ear
OR difficulty swallowing
OR loss of taste
Creatine kinase, total, serum (CK):
Increased: Male CK ≥ 208 U/L [chemistry report]
Female CK ≥ 169 U/L [chemistry report]
Reference ranges: Male 38 - 174 U/L
Female 26 - 140 U/L
Creatine kinase isoenzymes, serum:
Increased: total CK and CK-MB increase above reference values within 3 - 4 h
following myocardial infarction. Peak values are seen at 24 - 36 h, with return to
normal within 3 d.
Reference ranges: CK-MB 4 - 6 % of total CK [chemistry report]
0 - 10 U/L
0 - 9 μg/L
Creatine kinase isoforms:
Measured by high voltage electrophoresis. Formed in the blood by action of
proteolytic enzymes.
Increased: CK3c/CK3a ratio > 3.0
Increases within 1 - 2 h after myocardial infarction
(earlier than CK-MB) and peaks at 10 - 12 h
Reference ranges: CK-3a 42 - 75 % of total CK
CK-3b 18 - 51 % of total CK
CK-3c 2 - 14 % of total CK
CK3c/CK3a ratio 0.31 - 2.5
Creatine kinase relative index:
Useful in diagnosis of myocardial infarction when skeletal muscle trauma causes
increase in CK-MM
CK-MB μg/L
------------ x 100
Total CK U/L
Increased: CK relative index > 4.5
Reference range: CK relative index < 3.9 %
Creatine phosphokinase (CPK): See Creatine kinase
G-10