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Disease staging: CliniCal anD CoDeD Criteria - HCUP

Disease staging: CliniCal anD CoDeD Criteria - HCUP

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Iron Deficiency:<br />

Anemia<br />

AND Serum iron ≤35 μg/dL in females or ≤ 55 μg/dL in males [chemistry report]<br />

AND Total iron binding capacity ≥ 513 μg/dL [chemistry report]<br />

OR Serum ferritin ≤10 ng/mL [chemistry report]<br />

OR Iron depletion of bone marrow [bone marrow biopsy report]<br />

Reference ranges: Iron, serum Child 50 - 120 μg/dL<br />

Male 65 - 175 μg/dL<br />

Female 50 - 170 μg/dL<br />

Iron binding capacity Adult 250 - 425 μg/dL<br />

Ferritin, serum Male 20 - 250 ng/mL<br />

Female 10 - 120 ng/mL<br />

Jaundice: See hyperbilirubinemia<br />

Lactate dehydrogenase, serum (LD):<br />

Serum measurements have little organ specificity unless isoenzymes are measured.<br />

Reference ranges: Highly method dependent<br />

Adult: 140 - 280 U/L<br />

Lactate dehydrogenase isoenzymes:<br />

There are five isoenzymes which have been numbered LD-1 to LD-5. Ordinarily<br />

LD-2 is present in greater activity than LD-1; Because myocardium contains LD-1,<br />

following myocardial infarction the ratio LD-1/LD-2 becomes greater than 1.0 (the<br />

“flipped” pattern).<br />

LD: See Lactate dehydrogenase<br />

LDH: See Lactate dehydrogenase<br />

Leukocytosis:<br />

Increased: Leukocytes, blood > 12.6 x 10 3 /μL [CBC report]<br />

Reference Range: 4.5 - 11.0 x 10 3 /μL<br />

Leukocyte (neutrophil) alkaline phosphatase (LAP):<br />

Decreased: Score < 20<br />

Reference range: Score 40 - 130<br />

(Score is based on 0 - 4+ rating of 100 neutrophils)<br />

Leukopenia:<br />

Decreased: Leukocytes, blood < 3.0 x 10 3 /μL [CBC report]<br />

Severe decrease: Leukocytes, blood < 0.5 x 10 3 /μL<br />

Reference Range: 4.5 - 11.0 x 10 3 /μL<br />

G-22

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