Disease staging: CliniCal anD CoDeD Criteria - HCUP

Haptoglobin, serum:
Decreased: < 30 mg/dL [chemistry report]
Reference range: 40 - 240 mg/dL
Hematuria:
Females ≥4 red blood cells/hpf [urinalysis report]
Males ≥1 red blood cell/hpf[urinalysis report]
Hemoglobin A 2, blood:
Chromatographic method:
Increased: 3.7 - 7.0 % in β-thalassemia trait [hematology report]
Reference range: 1.5 - 3.5 %
Hemoglobin S, blood:
Sickle cell trait: Hemoglobin S > 20 % of total [Hemoglobin electrophoresis report]
AND Hemoglobin A > 60 % of total [Hemoglobin electrophoresis report]
Sickle cell disease: Hemoglobin S > 80% of total [Hemoglobin electrophoresis
report]
AND Hemoglobin F > 2 % of total [Hemoglobin electrophoresis report]
Hemolysis:
Serum haptoglobin ≤ 30 mg/dL [chemistry report]
OR Total serum bilirubin ≥ 1.4 mg/dL [chemistry report]
AND Unconjugated serum bilirubin > 80% of total bilirubin [chemistry
report]
OR Chromium labeled erythrocyte T 1/2 survival time ≤ 25 days
[Nuclear Medicine report]
Reference Ranges: Haptoglobin, serum 40 - 240 mg/dL
Total bilirubin, serum 0.3 - 1.2 mg/dL
Erythrocyte survival time T 1/2 25 - 32 days
Hemophilia:
Asymptomatic: Factor VIII ≥ 25 % and ≤ 50 % of normal [chemistry report]
Mild: Factor VIII < 25 % of normal [chemistry report]
Moderate: Factor VIII ≤ 5 % of normal [chemistry report]
Severe: Factor VIII not detected [chemistry report]
Hepatic Coma:
History of severe liver disease
AND Coma
OR Hepatic encephalopathy
OR Portal systemic encephalopathy
Deleted:
Deleted:
Deleted:
Hemoglobin electrophoresis
G-16