Pharmaceutical Technology: Controlled Drug Release, Volume 2

MULTIPARTICULATES [CH. 12 137
Fig. 5—Influence of thermal treatment on the drug release from tablets containing 15% LMW DL-PLA, 25%
theophylline and 60% microcrystalline cellulose.
dissolution rate of tablets after thermal treatment. However, our preliminary results also suggest
that the ratio of drug to excipient and the properties of the excipient may also exert a significant
influence on the retardation mechanism of thermally treated compacts.
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