Pharmaceutical Technology: Controlled Drug Release, Volume 2

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INDEX 195 nifedipine, 103 non-linear regression, 15 ocular retention, 167 ophthalmic formulations, 151, 160 effect of complexation, 165 effect of gelling, 165 solution drainage, 167 optimization, 41, 54, 103 oscillating granulator, 44 paracetamol, 103 particle size distributions, 58, 85, 111, 143 partition coefficient, 97 patient compliance, 69 penetrometer, 72 permeation, 87 pH variations, 16, 23, 145 pharmacokinetics, 85, 115 phenobarbitone, 139 phosphate buffers, 29 physiocochemical characteristics, 85 physics of compression, 44, 68 plasma levels, 85 polyacrylayte (Eudragit), 103 poly(caprolactone), 130, 132 poly(DL-lactic acid), 139 polyethyleneglycol (PEG), 27, 87, 95, 172 polygalacturonic acid (PGA), 160 polyisobutadiene, 115 poly(lactic acid), 130, 132 polymethylmethacrylate, 171 polymer-polymer interaction, 21 polyvinylalcohol (PVA), 87 polyvinylchloride (PVC), 32, 41, 54 polyvinylpyrrolidone (PVP), 13, 80 cross-linked, 80 pore tortuosity, 29, 36 potassium chloride, 32 powder flow, 43, 51, 59 Jenike shear cell, 60, 68 Precirol, 71, 80 retardant, 74 precompression, 41, 45, 65 principle component analysis (PCA), 59, 65 promethazine, 26 propranolol, 26, 87 protective colloid, 115 PVM-MA structure, 155 pulsed release, 78, 81 quinine, 26 rabbit osteomyelitic model, 174 reservoir system, 79 salting out, 25 scanning electron microscopy (SEM), 103, 118, 143, 175 gold coating, 109 sodium starch glycollate, 80 solvent evaporation process, 103 stirring rate, 110 superdisintegrants, 80, 83 suppression of ionization, 24 sustained release, 13, 21, 123 tablet shape, 21 talc, 41, 80 tear fluid, 155 tetracycline, 26 theophylline, 26, 103, 115 three-layer tablet, 78, 81 timolol maleate, 155 liquid scintillation count, 156 radioreceptor assay, 156 tobramycin sulphate, 171 topical release, 87 transdermal patches, 90 trapezoidal method, 125 turbidity, 24 USP dissolution methods, 32, 44, 72, 81, 118, 131 verapamil, 123 water of hydration, 21 wax matrices, 32 Weibull model, 49 wet granulation, 13, 43, 54, 65 zero order release, 20, 72, 96, 156, 164
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PHARMACEUTICAL TECHNOLOGY Controlle
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3 TABLET MACHINE INSTRUMENTATION IN
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First published in 1991 by ELLIS HO
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7 10 Controlled delivery of theophy
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Slow and steady wins the race Poems
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1 Influence of drug solubility in t
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CH. 1] INFLUENCE OF DRUG SOLUBILITY
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24 MATRIX FORMULATIONS [CH. 2 MATER
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26 MATRIX FORMULATIONS [CH. 2 Fig.
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28 MATRIX FORMULATIONS [CH. 2 Table
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30 MATRIX FORMULATIONS [CH. 2 The e
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34 CH. 3] THE FORMULATION OF SUSTAI
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4 Statistical optimization of a con
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MATRIX FORMULATIONS [CH. 4 45 (4) G
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MATRIX FORMULATIONS [CH. 4 47 Fig.
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Columns 1-4 lead to the matrix of e
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MATRIX FORMULATIONS [CH. 4 51 Table
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MATRIX FORMULATIONS [CH. 4 53 Fig.
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Fig. 5—Linearization of the relea
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58 MATRIX FORMULATIONS [CH. 5 Pevik
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60 MATRIX FORMULATIONS [CH. 5 The d
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6 Controlled release matrix tablets
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CH. 6] CONTROLLED RELEASE MATRIX TA
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7 A new ibuprofen pulsed release or
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CH. 7] A NEW IBUPROFEN PULSED RELEA
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90 CH. 8] TOPICAL RELEASE AND PERME
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100
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102
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104 MULTIPARTICULATES [CH. 9 parace
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106 MULTIPARTICULATES [CH. 9 (a) th
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108 MULTIPARTICULATES [CH. 9 Fig. 2
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116
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118 CH. 10] CONTROLLED DELIVERY OF
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126 CH. 11] THE EFFECT OF FOOD ON G
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128 CH. 11] THE EFFECT OF FOOD ON G
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130
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132 CH. 12] BIODEGRADABLE POLYMERS
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140
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142 CH. 13] A COMPARISON OF DISSOLU
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Page 157 and 158: 156 OPHTHALMIC FORMULATION [CH. 14
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Page 173 and 174: 172 IMPLANTS [CH. 16 The purpose of
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Page 185 and 186: 184 CH. 17] SILICON MATRIX SYSTEMS
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Page 195: 194 INDEX dry granulation, 43 elect
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