Pharmaceutical Technology: Controlled Drug Release, Volume 2

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CH. 5] AN OPTIMIZED PROLONGED RELEASE FORMULATION 63 Table 3—Porosimetry measurements a Pore diameter when cumulative volume is 50%. (2) It is easy to observe the important effect of UPF: the pore size distributions tend to go to the right as UPF increases; this means that, for the same accumulated intrusion volume, the mean pore diameter is smaller as UPF increases. In accordance with the growing UPF values, the pore size distributions are more to the right in the following order: Process UPF (kN) Wet granulation 7 Direct compression in Frogerais 7 Direct compression on Betapress 7 Double compression 12 Separate compaction 19 Compaction of the mixture 31 From the analysis, it is possible to suppose that the UPF applied on the Betapress rotary machine must be found between 7 and 12 kN. (3) The effect of UPF is verified by observing the similar pore size distributions of the wet granulation and the direct compression tablets in Frogerais, after 25% of the cumulative volume.
64 MATRIX FORMULATIONS [CH. 5 Fig. 2—The pore size distributions of the optimized tablets. Therefore the pore size distribution seems to be dependent on the applied compression force rather than the process, when the formula and the area under the dissolution curve were kept constant. Comparison fo the dissolution profiles Estimated F ∞ and β parameters from the Weibull Function The estimated F ∞ and β parameters are given in Table 4. The double compression process results in significant retention of the drug in the inert matrix 14 h after the dissolution test (F ∞ =0.87). Fig. 3 illustrates the effect of the process on the same formula and for near AUC values. The wet granulation release profile exhibits a marked sigmoid aspect owing to the high β value. Table 4—Estimates F∞ and β parameters
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PHARMACEUTICAL TECHNOLOGY Controlle
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3 TABLET MACHINE INSTRUMENTATION IN
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First published in 1991 by ELLIS HO
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7 10 Controlled delivery of theophy
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Slow and steady wins the race Poems
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114 MULTIPARTICULATES [CH. 9 Fig. 8
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118 CH. 10] CONTROLLED DELIVERY OF
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126 CH. 11] THE EFFECT OF FOOD ON G
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128 CH. 11] THE EFFECT OF FOOD ON G
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132 CH. 12] BIODEGRADABLE POLYMERS
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142 CH. 13] A COMPARISON OF DISSOLU
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156 OPHTHALMIC FORMULATION [CH. 14
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162 CH. 15] A SUSTAINED RELEASE OPH
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172 IMPLANTS [CH. 16 The purpose of
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174 IMPLANTS [CH. 16 times with 5 m
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176 IMPLANTS [CH. 16 noted that the
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178 IMPLANTS [CH. 16 Fig. 1—The e
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180 IMPLANTS [CH. 16 Table 3—Tobr
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184 CH. 17] SILICON MATRIX SYSTEMS
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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