Pharmaceutical Technology: Controlled Drug Release, Volume 2

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MATRIX FORMULATIONS [CH. 4 51 Table 5—Hadamard matrix H(8) results Fig. 2—<strong>Release</strong> profiles from the study of main effects. CONCLUSION From a minimum number of experiments, the Hadamard matrix gives the possibility of estimating the mean effects of four parameters. Among them, the particle size range had the most important effect in the release of diclofenac sodium. By interpreting data, a factorial design including only two parameters was applied from which an optimum formulation was found. As expected, when compared with the direct compression results [13], double compression considerably enhanced the flow of the powder and substantially decreased the variability between tablets. The drug release followed the Weibull distribution. The inert matrix formulation provided by ethylcellulose and Pevikon (polyvinyl chloride) was an effective vehicle for controlled release drug delivery systems.
52 CH. 4] STATISTICAL OPTIMIZATION OF A CONTROLLED RELEASE FORMULATION Table 6—Results from the analysis of variance (F values) Table 7—22 f actorial design Table 8—Results from the 22 f actorial design ACKNOWLEDGEMENTS The authors express their gratitude to A.T.Luong, general manager of Searle, Sophia Antipolis, for his helpful comments. Angelina Peña Romero wishes to thank El Consejo Nacional de Ciencia y Tecnología, La Facultad de Estudios Superiores de la Universidad Nacional Autónoma de Mexico, Le Comité d’Etudes sur la Formation d’lngénieurs, Paris, and Searle, Sophia Antipolis, for their moral and financial support. REFERENCES 1 [] B.B.Sheth, F.J.Bandelin and R.F.Shangraw, in <strong>Pharmaceutical</strong> Dosage Forms: Tablets, Vol. 1, Dekker, New York, 1980, pp. 127–128, 173, 177.
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162 CH. 15] A SUSTAINED RELEASE OPH
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184 CH. 17] SILICON MATRIX SYSTEMS
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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