Pharmaceutical Technology: Controlled Drug Release, Volume 2

MULTIPARTICULATES [CH. 13 149
Fig. 5—‘Higuchi’ plot of the release of phenobarbitone from phenobarbitone-DL-PLA tablets. Systems and ratios:
microcapsules 1:1; 2:1; matrices 1:1; 2:1; compressive forces (a) 2 kN, (b) 5 kN and (c) 10 kN. Dissolution conditions:
Buffer pH2; stirring rate, 100 rev min −1 ; t=37°C.
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2 [] W.A.Ritschel, in E.J.Ariens (ed.), Drug Design, Vol. IV, Academic Press, New York, 1973, p. 37.
3 [] D.A.Wood, in A.T.Florence (ed.), Materials Used in Pharmaceutical Formulation, Blackwell, London, 1984,
p. 77.
4 [] R.K.Kulkarni, K.C.Pani, C.Neuman and F.Leonard, Arch. Surg., 93, 839 (1966).
5 [] S.Yolles, D.J. E.Eldridge and J.H. R.Woodland, Polym. News, 1, 9 (1971).
6 [] L.R.Beck, D.R.Cowsar, D.H.Lewis, J.W.Gibson and C.E.Flowers, Am. J. Obstet. Gynecol, 135, 419 (1979).