Pharmaceutical Technology: Controlled Drug Release, Volume 2

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MULTIPARTICULATES [CH. 12 137 Fig. 5—Influence of thermal treatment on the drug release from tablets containing 15% LMW DL-PLA, 25% theophylline and 60% microcrystalline cellulose. dissolution rate of tablets after thermal treatment. However, our preliminary results also suggest that the ratio of drug to excipient and the properties of the excipient may also exert a significant influence on the retardation mechanism of thermally treated compacts. REFERENCES 1 [] R.K.Kulkarni, E.G.Moore, A.F.Hegyeli and F.Leonard, J. Blomed. Mater. Res., 5, 169 (1971). 2 [] M.Anderson and F.Gibbons, Biomater., Med. Dev., Ary, Org., 2(3), 235 (1974). 3 [] S.Yolles and M.F.Sartori, in A.Kydonieus (ed.), Controlled Release Technology: Erodible Matrices, CRC Press, Boca Raton, 1980, p. 1. 4 [] B.Farhadieh, S.Borodkin and J.D.Buddenhagen, J. Pharm. Sci., 60, 209 (1971). 5 [] C.G.Pitt, M.M.Gratzl, A.R.Jeffcoat and R.Zweidinger, J. Pharm. Sci., 68, 1534 (1979). 6 [] J.Heller and R.W.Baker, Theory and Practice of Controlled Drug Delivery from Biodegradable Polymers, Academic Press, New York, 1980. 7 [] A.Schindler, J.F.Kimble and G.Pitt, Contemporary Topics in Polymer Science, Vol. 2, Plenum, New York, 1977, p. 271. 8 [] R.Bodmier and J.W.McGinity, Pharm. Res., 4, 465 (1987). 9 [] R.Chang, J.Price and C.Whitworth, Drug Dev. Ind. Pharm. 12(14), 2355 (1986). 10 [] Handbook of Pharmaceutical Excipients, Vol. 1, American Pharmacetical Association, Washington, DC, 1986, p. 53.
138 CH. 12] BIODEGRADABLE POLYMERS Fig. 6—Influence of thermal treatment on the drug release from tablets containing 15% LMW DL-PLA, 60% theophylline and 25% microcrystalline cellulose. Fig. 7—Influence of thermal treatment on the drug release from tablets containing 15% LMW L-PLA, 25% theophylline and 60% microcrystalline cellulose.
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PHARMACEUTICAL TECHNOLOGY Controlle
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3 TABLET MACHINE INSTRUMENTATION IN
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First published in 1991 by ELLIS HO
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7 10 Controlled delivery of theophy
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Slow and steady wins the race Poems
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1 Influence of drug solubility in t
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CH. 1] INFLUENCE OF DRUG SOLUBILITY
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24 MATRIX FORMULATIONS [CH. 2 MATER
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26 MATRIX FORMULATIONS [CH. 2 Fig.
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28 MATRIX FORMULATIONS [CH. 2 Table
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30 MATRIX FORMULATIONS [CH. 2 The e
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34 CH. 3] THE FORMULATION OF SUSTAI
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4 Statistical optimization of a con
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MATRIX FORMULATIONS [CH. 4 45 (4) G
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MATRIX FORMULATIONS [CH. 4 47 Fig.
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Columns 1-4 lead to the matrix of e
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MATRIX FORMULATIONS [CH. 4 51 Table
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MATRIX FORMULATIONS [CH. 4 53 Fig.
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Fig. 5—Linearization of the relea
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58 MATRIX FORMULATIONS [CH. 5 Pevik
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60 MATRIX FORMULATIONS [CH. 5 The d
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6 Controlled release matrix tablets
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CH. 6] CONTROLLED RELEASE MATRIX TA
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7 A new ibuprofen pulsed release or
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CH. 7] A NEW IBUPROFEN PULSED RELEA
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Page 88: CH. 7] A NEW IBUPROFEN PULSED RELEA
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Page 105 and 106: 104 MULTIPARTICULATES [CH. 9 parace
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Page 157 and 158: 156 OPHTHALMIC FORMULATION [CH. 14
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188 CH. 17] SILICON MATRIX SYSTEMS
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190 CH. 17] SILICON MATRIX SYSTEMS
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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