Pharmaceutical Technology: Controlled Drug Release, Volume 2

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CH. 2] THE EFFECT OF ELECTROLYTES AND DRUGS 31 Fig. 2—Dissolution profiles of propanolol hydrochloride from HPMC K15M matrices into media, buffered to pH 6.0 containing various solutes. only water should be used as the dissolution medium for fundamental studies into drug release. However, physiological conditions need to be considered further.
32 MATRIX FORMULATIONS [CH. 2 Table 5—The effect of solute and ionic strength in the dissolution rate of propranolol hydrochloride from HPMC K15M matrix tablets REFERENCES 1 [] J.L.Ford, M.H.Rubinstein and J.E.Hogan, Int. J. Pharm., 24, 327 (1985). 2 [] J.L.Ford, M.H.Rubinstein and J.E.Hogan, Int. J. Pharm., 24, 339 (1985). 3 [] J.L.Ford, M.H. ubinstein, F.McCaul, J.E.Hogan and P.J.Edgar, Intg. Pharm., 40, 223 (1987). 4 [] N.Sarkar, J. Appl. Polym. Sci., 24, 1073, (1979). 5 [] P.G.Fagan, P.J.Harrison and N.Shankland, J. Pharm. Pharmacol. (1989), in press. 6 [] Alderman (1984). 7 [] J.L. Ford, M.H. Rubinstein, A. Changela and J.A. Hogan, J. Pharm. Pharmacol., 37, 115P (1985). 8 [] E.Touitou and M. Donbrow, Int. J. Pharm., 11, 131 (1982). 9 [] A.T.Florence and R.T.Parfitt, J. Pharm. Pharmacol., 22, 121S (1970). 10 [] G.Levy and T.W.Schwarz, J. Am. Pharm. Assoc. Sci. Edn., 47, 44 (1958). 11 [] I.R.Katz and F.W.Muschter, Biochem. Z., 257, 385 (1933). 12 [] A.R.Fasshi and D.L.Mundy, J. Pharm. Pharmacol., 41, 369 (1989).
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CH. 7] A NEW IBUPROFEN PULSED RELEA
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90 CH. 8] TOPICAL RELEASE AND PERME
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104 MULTIPARTICULATES [CH. 9 parace
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106 MULTIPARTICULATES [CH. 9 (a) th
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108 MULTIPARTICULATES [CH. 9 Fig. 2
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118 CH. 10] CONTROLLED DELIVERY OF
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126 CH. 11] THE EFFECT OF FOOD ON G
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128 CH. 11] THE EFFECT OF FOOD ON G
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132 CH. 12] BIODEGRADABLE POLYMERS
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142 CH. 13] A COMPARISON OF DISSOLU
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156 OPHTHALMIC FORMULATION [CH. 14
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162 CH. 15] A SUSTAINED RELEASE OPH
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172 IMPLANTS [CH. 16 The purpose of
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174 IMPLANTS [CH. 16 times with 5 m
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176 IMPLANTS [CH. 16 noted that the
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178 IMPLANTS [CH. 16 Fig. 1—The e
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180 IMPLANTS [CH. 16 Table 3—Tobr
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184 CH. 17] SILICON MATRIX SYSTEMS
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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