Pharmaceutical Technology: Controlled Drug Release, Volume 2

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MATRIX FORMULATIONS [CH. 8 95 Table 3—In vitro release-permeation of propranolol hydrochloride from Methocel ® matrix formulation in the presence of the additive ingredients using cellulose membrane Average of three determinations. Table 4—<strong>Drug</strong> release from Methocel® matrix formulation containing varied concentrations of polymer using the cellulose membrane Average of three determinations. I, drug:polymer ratio=1:1.5; II, drug:polymer ratio=1:2.0; III, drug:polymer ratio=1:3.0. Permeation studies using hairless mouse skin The Methocel ® matrix, formulation A, was further investigated using the hairless mouse skin as the diffusion barrier. Here the drug release was observed to be reduced significantly to 1.3mg/ (24h) compared with 11.75 mg/(24h) through the cellulose membrane. The formulation was further modified with the inclusion of
96 CH. 8] TOPICAL RELEASE AND PERMEATION STUDIES Table 5—<strong>Drug</strong> release from Methocel® matrix formulation containing varied concentrations of propranolol hydrochloride Average of three determinations. Fig. 2—Effect of drug loading on the release profile of propranolol hydrochloride from Methocel ® matrix: , 3.0%; , 2.0%; □, 1.0%; ○, 0.5%. DMSO in an effort to enhance drug release through the hairless mouse skin. When the diffusion membrane itself was soaked with DMSO for 1 h prior to its use, the drug release-permeation was increased by 40% (Table 6 and Fig. 3). The release patterns of the drug were linear from the samples containing in some way small amounts of DMSO. The sample without DMSO provided linear release only up to the first 12 h period of the study. This could be attributed to the complicated processes involved in the passive diffusion of the drug through the skin. The linear release suggest that the drug release was zero order. Using these data, some of the related parameters, i.e. rate constant (K), correlation coefficient (r) and the values for the Y intercepts, were calculated (Table 7). Comparing these data
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PHARMACEUTICAL TECHNOLOGY Controlle
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3 TABLET MACHINE INSTRUMENTATION IN
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First published in 1991 by ELLIS HO
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7 10 Controlled delivery of theophy
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Slow and steady wins the race Poems
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1 Influence of drug solubility in t
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CH. 1] INFLUENCE OF DRUG SOLUBILITY
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24 MATRIX FORMULATIONS [CH. 2 MATER
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26 MATRIX FORMULATIONS [CH. 2 Fig.
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28 MATRIX FORMULATIONS [CH. 2 Table
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30 MATRIX FORMULATIONS [CH. 2 The e
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32 MATRIX FORMULATIONS [CH. 2 Table
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34 CH. 3] THE FORMULATION OF SUSTAI
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4 Statistical optimization of a con
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146 CH. 13] A COMPARISON OF DISSOLU
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156 OPHTHALMIC FORMULATION [CH. 14
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162 CH. 15] A SUSTAINED RELEASE OPH
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172 IMPLANTS [CH. 16 The purpose of
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174 IMPLANTS [CH. 16 times with 5 m
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176 IMPLANTS [CH. 16 noted that the
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178 IMPLANTS [CH. 16 Fig. 1—The e
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180 IMPLANTS [CH. 16 Table 3—Tobr
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184 CH. 17] SILICON MATRIX SYSTEMS
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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