Pharmaceutical Technology: Controlled Drug Release, Volume 2
Pharmaceutical Technology: Controlled Drug Release, Volume 2
Pharmaceutical Technology: Controlled Drug Release, Volume 2
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64 MATRIX FORMULATIONS [CH. 5<br />
Fig. 2—The pore size distributions of the optimized tablets.<br />
Therefore the pore size distribution seems to be dependent on the applied compression force<br />
rather than the process, when the formula and the area under the dissolution curve were kept<br />
constant.<br />
Comparison fo the dissolution profiles<br />
Estimated F ∞ and β parameters from the Weibull Function<br />
The estimated F ∞ and β parameters are given in Table 4.<br />
The double compression process results in significant retention of the drug in the inert matrix<br />
14 h after the dissolution test (F ∞ =0.87).<br />
Fig. 3 illustrates the effect of the process on the same formula and for near AUC values. The<br />
wet granulation release profile exhibits a marked sigmoid aspect owing to the high β value.<br />
Table 4—Estimates F∞ and β parameters