Pharmaceutical Technology: Controlled Drug Release, Volume 2
Pharmaceutical Technology: Controlled Drug Release, Volume 2
Pharmaceutical Technology: Controlled Drug Release, Volume 2
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CH. 5] AN OPTIMIZED PROLONGED RELEASE FORMULATION 65<br />
Fig. 3—Effect of the process on the release profiles.<br />
Analysis of covariance<br />
The analysis of covariance between a continuous variable (β is the curve shape parameter from the<br />
Weibull function) and a discrete variable (process) was determined using the general linear model<br />
(GLM) procedure from the Statistical Analysis System (SAS). The technique of the heterogeneity<br />
of slopes showed that there was no significant difference (Tables 5 and 6).<br />
Table 5—R 2 and β values<br />
(1) between the two direct compression processes performed in a single-punch machine (β=1.51)<br />
and in rotary machine (β=1.65), or<br />
(2) between the formula obtained by compaction by the five raw materials (β=2.68) and the<br />
formula obtained by double compression (β=2.46).<br />
As the other comparisons between slopes are significant (p
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