Pharmaceutical Technology: Controlled Drug Release, Volume 2

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CH. 1] INFLUENCE OF DRUG SOLUBILITY IN THE FORMULATION OF HYDROPHILIC MATRICES 19 Fig. 5—Drug release for formula 8. Fig. 6—Drug release for formulae 8 and 12. Natrosol (formula 12: t 50 =1.18 h) (Fig. 6). Standard deviations are very low in all tests (
20 MATRIX FORMULATIONS [CH. 1 Fig. 7—Effect of pH for drug B. Fig. 8—Effect of amount of HPMC on drug release for drug B. Drug C The physical characteristics of this drug are similar to those of drug B; dissolution rates are also similar with the same quantity of HMPC (formula 14: t 50 =2.16 h). When the amount of HPMC is increased, the dissolution rate decreases, but slowly (Fig. 9). CONCLUSION Formulation of hydrophilic matrices with a release time longer than 8 h is difficult with drugs B and C, owing to the high solubility of the substances; contrary to slightly soluble drugs (e.g. drug A), zero-order release cannot be obtained by classical means. However, in this case, the dissolution rate is more sensitive to the quantities of hydrophilic polymer present, fabrication process, nature of the diluent and/or pH variations in the dissolution medium.
Page 2 and 3: PHARMACEUTICAL TECHNOLOGY Controlle
Page 4 and 5: 3 TABLET MACHINE INSTRUMENTATION IN
Page 6 and 7: First published in 1991 by ELLIS HO
Page 8 and 9: 7 10 Controlled delivery of theophy
Page 10: Slow and steady wins the race Poems
Page 14 and 15: 1 Influence of drug solubility in t
Page 16 and 17: CH. 1] INFLUENCE OF DRUG SOLUBILITY
Page 18 and 19: CH. 1] INFLUENCE OF DRUG SOLUBILITY
Page 22: CH. 1] INFLUENCE OF DRUG SOLUBILITY
Page 25 and 26: 24 MATRIX FORMULATIONS [CH. 2 MATER
Page 27 and 28: 26 MATRIX FORMULATIONS [CH. 2 Fig.
Page 29 and 30: 28 MATRIX FORMULATIONS [CH. 2 Table
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Page 35 and 36: 34 CH. 3] THE FORMULATION OF SUSTAI
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Page 50 and 51: Columns 1-4 lead to the matrix of e
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6 Controlled release matrix tablets
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CH. 6] CONTROLLED RELEASE MATRIX TA
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7 A new ibuprofen pulsed release or
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CH. 7] A NEW IBUPROFEN PULSED RELEA
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90 CH. 8] TOPICAL RELEASE AND PERME
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104 MULTIPARTICULATES [CH. 9 parace
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106 MULTIPARTICULATES [CH. 9 (a) th
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108 MULTIPARTICULATES [CH. 9 Fig. 2
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118 CH. 10] CONTROLLED DELIVERY OF
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126 CH. 11] THE EFFECT OF FOOD ON G
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128 CH. 11] THE EFFECT OF FOOD ON G
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132 CH. 12] BIODEGRADABLE POLYMERS
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142 CH. 13] A COMPARISON OF DISSOLU
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156 OPHTHALMIC FORMULATION [CH. 14
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162 CH. 15] A SUSTAINED RELEASE OPH
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170
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172 IMPLANTS [CH. 16 The purpose of
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174 IMPLANTS [CH. 16 times with 5 m
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176 IMPLANTS [CH. 16 noted that the
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178 IMPLANTS [CH. 16 Fig. 1—The e
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180 IMPLANTS [CH. 16 Table 3—Tobr
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184 CH. 17] SILICON MATRIX SYSTEMS
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192
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194 INDEX dry granulation, 43 elect
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Pharmaceutical Technology: Controlled Drug Release, Volume 2

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