Trimellitate Category; Revised Summaries - US Environmental ...

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MMN budy welphl(& d ~~BLS exposed LY this chetuica1 Malts Initial H’Plght 26EJ(SAD) Fcnralcs Firs1 week Serond week Initial weight First ws+ek second week 2977.8(14.01) 329.7CK27) 213.9{2.6h) 223.2(3.96) 238.1(4.82 3 Fmd/wufer cmsumptiorr: No detailed data available. cciniml signs ! AIL animals (male and female) had matted, drenched coats for the first 2 days, otherwise no visible signs. HiW7lUfUiU~: Not done Biochmr Not done. OpLfhRallmolt3gic~mfings: Eciot twmined. MtwMig arrd rime r~ death: No deaihs were recorded. urgan wsighf changes: No1 done. Genen2l nacropsy obsm~iztiom: All males and 3/5 females exhibited reddening patches 011 lungs. CONCL<strong>US</strong>lONS LQ, was 2,600 mg.‘m’ for both sexes. DATA QUALITY . R&abilities: KJimiscb Code: l=rcliable without rcsuktions. . Remarks Geld for Data Reliability: Well conducted sudy, carried out by Midwest Research Institute. Nuodex Inc, Acule inhalation toxicity lest in SpragueDawley rats using colmpoundNcqlaz 6959 <strong>Environmental</strong> Protection Agency (1%3) GENERAL REMARKS
mST SUBSTANCE . Idcnlity: ~js(2-ethylhexyl}benzene-1,2,4-tricarboxyInte l Remnrks: Sburce: Nouplax 6959: Batch No. 39049 Purity: 93.95% DRAFT ENWM,‘EXCH(99)13 . Method! Procedure set forth in the Federal Insecticide, Fungicide, andlodenticjde Act (RFRA) . GLP: Yes . Year: 1981 l Species: Rabbits I Strain: New Zealand albino white rabhi& . Doseshw.entratian l~:vcls: 2.0 rnL/kg . Sex: Male W Female . Post exposure rr,bservPtion periud:Two weeks. . Ratistical mttbods: Nor applicable because of no latalizy. REMARKS PIELL) FOi? TEST C~NDJTICWJ RESULTS Test Subjects Study Design: PrucedurPr: 24 hours prior to treatment the hair on the back of each rabbit was clipped SO as to expose approxjmately 10% of ihc: hndy surface 3~3. Before dosing, epidermal abrasions were made longitudinally CWCY rhe exposure area. The abrasions were sufficiently deep to penetrate the stratum cOmeUrn but not SCI deep as 10 cause bleeding. A dosage was applied to the exposure area. A 2 x 2-inch gauze pad was placed on the exposure area to prevent seepage of the compound frcsm 1h.e area. Each animal was then wrapped with a rubber dam. After 24 hour of exposure, rhe rubber dam anrj gauze pad were removed, and the exposure area was wiped to remove any remaining tat material. Satellite groups rind reu.su~ Lhsy wwe added; Acme Chid obseuv~‘ons perfot-md andfrieguencp; After the exposure, all animals were observed daily for 14 days for clinical signs of toxicity. A gross ntcrapsy was performed an all animals at the end of the 14 day observation period. I LD,,: MaIe : > 2.0 mukg Female : S. 2.p mL/kg 41
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IUCLID Data Set Existing Chemical :
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1. General Information Id 3319-31-1
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2. Physico-Chemical Data Id 3319-31
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3. Environmental Fate and Pathways
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5. Toxicity Id 3319-31-1 5.1 .I ACU
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5. Toxicity Id 3319-31-1 Test condi
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6. References Id 3319-31-1 (3) (4)
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1. General Information Id 27251-75-
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c 3. Environmental Fate and Pathway
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5. Toxicity Id 27251-75-8 51.1 ACUT
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7. Risk Assessment Id 27251-75-8 7.
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! 1. General Information Id 53894-2
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i 2. Physico-Chemical Data Id 53894
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- 4. Ecotoxicity 4.1 ACUTE/PROLONGE
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6. References Id 53894-23-8 Date 15
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1. General Information Id 67989-23-
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5. Toxicity Id 67989-23-5 5.1 .I AC
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7. Risk Assessment Id 67989-23-5 7.
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Summary of SIDS Information on Trim
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3319311S~AP910.doc I ll I The Macka
Page 55 and 56: 4.5.2 4.6.1 4.6.2 4,6.3 Ft!zT 5.1.1
Page 57 and 58: 1. IDENTITY IUPAC Name: CM Number:
Page 59 and 60: EKE dw Esrimated Human EXP~H.IJ~ Lo
Page 61 and 62: Chromosomal aberralion lest by OECD
Page 63 and 64: I Fidl __-__________. - . .._. -..-
Page 65 and 66: Eastman Kodak. Absorption sncl melA
Page 67 and 68: TJZST SUBSTANCE . lden Lily: h R~ma
Page 69 and 70: l Idenlily: . Rcma rks: METHOD . Me
Page 71: DRAFT ENV,‘JM/EXCH(99)13 VAPOR PR
Page 74 and 75: I Rcmnrks: -. _ - - -
Page 76: --. TEST SUTSTANCE + Tdcn tily; . I
Page 80 and 81: 4 Kelia bilities: Key sludy l Remar
Page 83 and 84: w + l + + l + + l + Method: VP@: GL
Page 85: --. - ,-.-.. .----_ -. -_ l Remarks
Page 88 and 89: CONCLUSIONS DATA QUALITY Mortality
Page 90 and 91: DRAFT EI’WJM/EXCHI[99)13 TIEST WE
Page 92 and 93: DATA QUMJTY . Rtliabilitie~: Khiscb
Page 94 and 95: DRAFT ENV/JM/EXCH(99)23 REsuLTs Nom
Page 96 and 97: TEST SUBSTANCE 1 Identity: Remarks:
Page 98 and 99: DRAFT’ ENV/JMIEXCH(99)13 c DATA Q
Page 100 and 101: DRAFf ENV/3M/EXCH(99)13 Nominal cxu
Page 103 and 104: ACUTE ORAL. TOXICITY DRAFT ENV/JM/E
Page 105: ACUTE IN-L4lA’~lON TOXJCJTY + Ide
Page 109 and 110: Diet - Wqne 15% Rabbit Rzltion and
Page 111 and 112: TEST SUBSTANCE l lden Lily: Tris(2-
Page 113 and 114: t - . KEFERENCES GENERAL REmRKS ~uu
Page 115 and 116: SENSIT~ ZATI ON TJ3T SUBSTANCE . Id
Page 117 and 118: I Iden tilyr . Rems rks: METHOD . l
Page 119 and 120: increased in the TOTM and DEEP trea
Page 121 and 122: IZST SUBSTANCE I Edcntity: l Remark
Page 123 and 124: Organ weighr chunges: ac A? md qfdm
Page 125 and 126: .l_.“. _.,“^---“~~, RESULTS P
Page 127 and 128: JDJ-LGFI’ EJWJM/EXC.X(99)13 No. o
Page 129 and 130: DRAFT ENV/JM/EXCH(99)13 Female Day
Page 131 and 132: 1 Genotoxic clbttsr With metabolic
Page 133 and 134: IIRAn ENV/JMfiXW(99)13 GENETIC TOXI
Page 135 and 136: air side air-water hfl’C 5 soil a
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