Trimellitate Category; Revised Summaries - US Environmental ...

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DRAFT ENV/JM/EXCH(99)13 GENETIC TOXICITY IN VITRO (BACTERIAL TEST) r TEST SUBSTANCE . Identity: . Remarks: METHOD . Method: . . . Test type: GLP: Year: Species/Strain: Positive controls: S9: Statistical methods REMARKS FIELD FOR TEST CONDITIONS . Study Design: I RESULTS . Cytotoxic concentration: Tris(2-ethylhexyl)benzene-1,2,4&carboxylate Source: Daihachi Kagaku Kogyo Co., Ltd. Lot. No. N-60601 Purity: >99.0% Kept at room temperature in a dark place until use. Guideline for ScreeningMutagenicity Testing of Chemicals(Japan) and OECD TG 471 and 472 Reverse mutation assay YeS 1996 Salmonella typhimurium TAlOO, TAlS35, TA98, TA1537 Escherichia coli WP2 rolrA -S9 mix, 2-(Z-Furyl)-3-(5nitro-2-furyl)acrylamide (TAlOO, WP2, TA98) Sodium azide (TA1535) 9-Aminoacridine (TA 1537) tS9 mix, 20kminoanthracene (five strains) Rat liver, induced withphenobarbital and 5,6-benzoflavone No statistical analysis was done. Concentrafion: -S9: 0,313, 62.5, 1,250,2,500,5,000 ug/plate (five strains) tS9: 0,313, 625, 1,250, 2,500,5,000 @plate (five strains) Number of replicates: 2 Ptiesltest: 3 Procedure: Plate incorporation method Solver& Acetone Positive controls: -S9 mix, 2-(2-Furyl)-3-(S-nitro-2&uyl)acrylamide (TAlOO, WP2, TA98) Sodium azide (TA1.535) 9-Aminoacridine (TA 1537) tS9 mix, 20Aminoanthracene (five strains) Toxicity was not observed up lo $000 ug/plate in five strains with and without metabolic activation (S9 mix). 64
1 Genotoxic clbttsr With metabolic activation: Without metabdic i-mivation RJDiARKS FIELD FOR RESULTS. DATA QUALITY Baclerial gene rinddon is neptive wilh and wjthout metabolic actjvalion. l Rdiahili ties: Valid wi~houtmtriction. REJ?ERJWC~ Well conducted study, carried out byHalano Rcscarti Institute, Food and Drug $afelyCcntcr {Had&m, Japan). -.. Toxicity Testing Reports of Envirnmnental Chemicals,vol.4(1996) Ministry of Health & Welfare, Japan 65
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IUCLID Data Set Existing Chemical :
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1. General Information Id 3319-31-1
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2. Physico-Chemical Data Id 3319-31
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3. Environmental Fate and Pathways
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5. Toxicity Id 3319-31-1 5.1 .I ACU
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5. Toxicity Id 3319-31-1 Test condi
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6. References Id 3319-31-1 (3) (4)
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1. General Information Id 27251-75-
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c 3. Environmental Fate and Pathway
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5. Toxicity Id 27251-75-8 51.1 ACUT
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7. Risk Assessment Id 27251-75-8 7.
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! 1. General Information Id 53894-2
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i 2. Physico-Chemical Data Id 53894
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- 4. Ecotoxicity 4.1 ACUTE/PROLONGE
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6. References Id 53894-23-8 Date 15
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1. General Information Id 67989-23-
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5. Toxicity Id 67989-23-5 5.1 .I AC
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7. Risk Assessment Id 67989-23-5 7.
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Summary of SIDS Information on Trim
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3319311S~AP910.doc I ll I The Macka
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4.5.2 4.6.1 4.6.2 4,6.3 Ft!zT 5.1.1
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1. IDENTITY IUPAC Name: CM Number:
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EKE dw Esrimated Human EXP~H.IJ~ Lo
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Chromosomal aberralion lest by OECD
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I Fidl __-__________. - . .._. -..-
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Eastman Kodak. Absorption sncl melA
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TJZST SUBSTANCE . lden Lily: h R~ma
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l Idenlily: . Rcma rks: METHOD . Me
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DRAFT ENV,‘JM/EXCH(99)13 VAPOR PR
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I Rcmnrks: -. _ - - -
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--. TEST SUTSTANCE + Tdcn tily; . I
Page 80 and 81: 4 Kelia bilities: Key sludy l Remar
Page 83 and 84: w + l + + l + + l + Method: VP@: GL
Page 85: --. - ,-.-.. .----_ -. -_ l Remarks
Page 88 and 89: CONCLUSIONS DATA QUALITY Mortality
Page 90 and 91: DRAFT EI’WJM/EXCHI[99)13 TIEST WE
Page 92 and 93: DATA QUMJTY . Rtliabilitie~: Khiscb
Page 94 and 95: DRAFT ENV/JM/EXCH(99)23 REsuLTs Nom
Page 96 and 97: TEST SUBSTANCE 1 Identity: Remarks:
Page 98 and 99: DRAFT’ ENV/JMIEXCH(99)13 c DATA Q
Page 100 and 101: DRAFf ENV/3M/EXCH(99)13 Nominal cxu
Page 103 and 104: ACUTE ORAL. TOXICITY DRAFT ENV/JM/E
Page 105 and 106: ACUTE IN-L4lA’~lON TOXJCJTY + Ide
Page 107 and 108: mST SUBSTANCE . Idcnlity: ~js(2-eth
Page 109 and 110: Diet - Wqne 15% Rabbit Rzltion and
Page 111 and 112: TEST SUBSTANCE l lden Lily: Tris(2-
Page 113 and 114: t - . KEFERENCES GENERAL REmRKS ~uu
Page 115 and 116: SENSIT~ ZATI ON TJ3T SUBSTANCE . Id
Page 117 and 118: I Iden tilyr . Rems rks: METHOD . l
Page 119 and 120: increased in the TOTM and DEEP trea
Page 121 and 122: IZST SUBSTANCE I Edcntity: l Remark
Page 123 and 124: Organ weighr chunges: ac A? md qfdm
Page 125 and 126: .l_.“. _.,“^---“~~, RESULTS P
Page 127 and 128: JDJ-LGFI’ EJWJM/EXC.X(99)13 No. o
Page 129: DRAFT ENV/JM/EXCH(99)13 Female Day
Page 133 and 134: IIRAn ENV/JMfiXW(99)13 GENETIC TOXI
Page 135 and 136: air side air-water hfl’C 5 soil a
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