Trimellitate Category; Revised Summaries - US Environmental ...

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7. Risk Assessment Id 3319-31-1 7.2 HAZARD SUMMARY Chapter Remark Attached dot. Flag 13.12.2001 7.3 RISK ASSESSMENT Memo Attached dot. Flag 13.12.2001 Date 13.12.2001 : Chapters 4 & 5 : Because of the similarity in chemical structure, the Panel believes that the toxicological properties of the substances in this category will be similar as well. Thus, the Panel considers that the data for the best tested member of this category, tris-2-(ethylhexyl) trimellitate (TOTM), also represents the potential for human and environmental effects of the other members of this category. TOTM has been sponsored under the OECD SIDS program through ICCA. A review of the available data for TOTM (see attached Table) indicates that all endpoints have been adequately addressed, and that TOTM exhibits a low order of toxicity. Due to their higher molecular weight and bulky side chains, the remaining members of this category are expected to demonstrate a lower order of toxicity than TOTM. This is supported by a similar structural-activity relationship observed with phthalate ester compounds, i.e., the higher molecular weight phthalates (ester side chains >C7) are less active that the transitional phthalates (ester side chains C4-C6). Thus, the use of TOTM to represent the potential hazards of the other category members is a conservative position. : Summary of SIDS Information on <strong>Trimellitate</strong>s.doc : Critical study for SIDS endpoint : SIDS Initial Assessment Profile (SIAP), SIDS Initial Assessment Report (SIAR) and Robust Summary for TOTM -- submitted by Japan under ICCA HPV program. : 1-l-T-M SIAR.pdf : Critical study for SIDS endpoint 16116
IUCLID Data Set Existing Chemical : ID: 27251-75-g CAS No. : 27251-75-8 TSCA Name : 1,2,4-benzenetricarboxcylic acid, triisooctyl ester Generic name : triisooctyl ester trimellitate Producer Related Part Company Creation date Substance Related Part Company Creation date : ExxonMobil Biomedical Sciences Inc. : 26.10.2000 : ExxonMobil Biomedical Sciences Inc. : 26.10.2000 Memo : ACC Phthalate Esters HPV Panel Printing date Revision date Date of last Update Number of Pages : 11 : 13.12.2001 : 30.102001
Page 1 and 2: IUCLID Data Set Existing Chemical :
Page 3 and 4: 1. General Information Id 3319-31-1
Page 5 and 6: 2. Physico-Chemical Data Id 3319-31
Page 7 and 8: 3. Environmental Fate and Pathways
Page 11 and 12: 5. Toxicity Id 3319-31-1 5.1 .I ACU
Page 13 and 14: 5. Toxicity Id 3319-31-1 Test condi
Page 15: 6. References Id 3319-31-1 (3) (4)
Page 19 and 20: 1. General Information Id 27251-75-
Page 23 and 24: c 3. Environmental Fate and Pathway
Page 25 and 26: 5. Toxicity Id 27251-75-8 51.1 ACUT
Page 27 and 28: 7. Risk Assessment Id 27251-75-8 7.
Page 29 and 30: ! 1. General Information Id 53894-2
Page 31 and 32: i 2. Physico-Chemical Data Id 53894
Page 35 and 36: - 4. Ecotoxicity 4.1 ACUTE/PROLONGE
Page 37 and 38: 6. References Id 53894-23-8 Date 15
Page 39 and 40: IUCLID Data Set Existing Chemical :
Page 41 and 42: 1. General Information Id 67989-23-
Page 47 and 48: 5. Toxicity Id 67989-23-5 5.1 .I AC
Page 49 and 50: 7. Risk Assessment Id 67989-23-5 7.
Page 51 and 52: Summary of SIDS Information on Trim
Page 53 and 54: 3319311S~AP910.doc I ll I The Macka
Page 55 and 56: 4.5.2 4.6.1 4.6.2 4,6.3 Ft!zT 5.1.1
Page 57 and 58: 1. IDENTITY IUPAC Name: CM Number:
Page 59 and 60: EKE dw Esrimated Human EXP~H.IJ~ Lo
Page 61 and 62: Chromosomal aberralion lest by OECD
Page 63 and 64: I Fidl __-__________. - . .._. -..-
Page 65 and 66: Eastman Kodak. Absorption sncl melA
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TJZST SUBSTANCE . lden Lily: h R~ma
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l Idenlily: . Rcma rks: METHOD . Me
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DRAFT ENV,‘JM/EXCH(99)13 VAPOR PR
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I Rcmnrks: -. _ - - -
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--. TEST SUTSTANCE + Tdcn tily; . I
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4 Kelia bilities: Key sludy l Remar
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w + l + + l + + l + Method: VP@: GL
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--. - ,-.-.. .----_ -. -_ l Remarks
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CONCLUSIONS DATA QUALITY Mortality
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DRAFT EI’WJM/EXCHI[99)13 TIEST WE
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DATA QUMJTY . Rtliabilitie~: Khiscb
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DRAFT ENV/JM/EXCH(99)23 REsuLTs Nom
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TEST SUBSTANCE 1 Identity: Remarks:
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DRAFT’ ENV/JMIEXCH(99)13 c DATA Q
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DRAFf ENV/3M/EXCH(99)13 Nominal cxu
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ACUTE ORAL. TOXICITY DRAFT ENV/JM/E
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ACUTE IN-L4lA’~lON TOXJCJTY + Ide
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mST SUBSTANCE . Idcnlity: ~js(2-eth
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Diet - Wqne 15% Rabbit Rzltion and
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TEST SUBSTANCE l lden Lily: Tris(2-
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t - . KEFERENCES GENERAL REmRKS ~uu
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SENSIT~ ZATI ON TJ3T SUBSTANCE . Id
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I Iden tilyr . Rems rks: METHOD . l
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increased in the TOTM and DEEP trea
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IZST SUBSTANCE I Edcntity: l Remark
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Organ weighr chunges: ac A? md qfdm
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.l_.“. _.,“^---“~~, RESULTS P
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JDJ-LGFI’ EJWJM/EXC.X(99)13 No. o
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DRAFT ENV/JM/EXCH(99)13 Female Day
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1 Genotoxic clbttsr With metabolic
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IIRAn ENV/JMfiXW(99)13 GENETIC TOXI
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Trimellitate Category; Revised Summaries - US Environmental ...

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