Trimellitate Category; Revised Summaries - US Environmental ...

DRAFT ENV/JM,‘EXCH(W)13
. NOAEL 134 mglkgbw
. LOUL 650 mdkg bu:
REMARKS FIELD FOR RESULTS.
Body weight:
Food intakes wert: measured over Ihc period day-3 to U and c.onGnuos intakes were
measured at twice-weekly intervals unlil the day preceding autopsy. The inlakes of test
article or reference compound for each animal svcrc calculaLed Lwicc weekly using the
snalysed dklary cnncenlratiOns of TOTM or DElO’, and the individual valued for
bodywighl and food intake.
Nernardogic p~~rcwwrers were evalua!Ed for each animaLOn the day preceding the
stm of the autopsies a sample of blood was collected from a caudal win of each
wkimal.
Ampy: At the end of the 2$ day treatment period the rats were deprived of’ fond
overnight, with water available.< On rhe day of autqq each animal was weighted and
then killed. The blood was used to provide sewn for clinical chemistry. During the
autopsy any abnormalitiesof the external condition and of tie tharacic or abdominal
viscera were noted.
Organs: The weight Df the follnwing organs were rcurded: adrenal glands, lungs,
brain, ~varjes, hear-~, spleen, kidneys, testes, liver, rhyruid.
Hec&on mkrosrapy: TWO thin slices of liar, one fraln the left lobe, the olhw from
the median lobe, were fixed for sndysis. (The remainder of the iiver was used for
biochemical analysis.)
Bi~cht~ziml L(PILI~@S of rhc livt~: Whole hctmagenateswere prepared nrld assayed
for protein and cyanide-Ltsensitivepalmit~yl-CoA.
No statistically significant differences Of bodJwdght between the control and TOThI
OT DEHP treated groups of either sex. There was a trend for the male rats frcrm all the
TOTM treated groups to be lighter than the cuntrols. In the females, this trend was only
evident ia the 2.0% ‘IDI’M gmup.
Foodlwcr&r cunsumption:Female rats fed 2,0% TOTM consumed significantly less diet than the
controls during first seven days of treatment afier which their intakes increased but
remained lower then those of the ~ntrols. In the males there were tx1 stalistically
significan! differencesbetwccn the control and TOTM fed groups during the It-eaiment
period.
Huem~Yology : In bath sexes haemaglobin concentration of the rats given diet containing 0.67 or 2,070
TOTM were statistically significantly lower than the control. Tn the males there was a
small lower@ of tqhrocyte count in all groups given TOTM but this was not
reproduced in the females.
Both sexes given the two higher dietary ccsnccntratimts of TOTM had higherieucocyte
cuun~s ihan the contt@ but the differences were sta~isti~lly significant unljn the
males, These male groups also had lower proportions of the lcucocytes aseosinophils
and mon0cytes.
Significantly Iclwcr values for baemcnocrit and mean cell volume were limited to
females given the IWO lower dose levels of TOM.
Orjyun wei#glcs : In bolh sexes the liver weights, and liver weights r&live to bodyweighl, were.