Trimellitate Category; Revised Summaries - US Environmental ...

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Sensitizatim tZs1 On guinea pig using OECI)/TG 406
sensitizaliorf’.
3-2 Initial Assessmcnf hr Human Health
(Tenneco C’hemkak, 198l)showcd ” no
acute toxicity of TOTM is considered to be I..J& >2OOO m&kg in rat.
In the irritation-tesl for animals, lWTh4 is slightly irrilaling P, Ihe skin and the c-ye
Sensitizatjnn test on guinea pig using OE~IXTG 406 shawedL1 no sensitization”.
The NOAEL and the LOAEL for repeated oral mxicity are considered IO be 100 and 3Qr~
rnglk@ay for ralg rcspeclively
The NOELs for reproductivdd~elopmental tc~xjcil!, were considered ta be 100 mg,fkg/day for
male rats, 1,Wl myj?‘kglday for fernalc rals, and 1,OOU nqg’kg’day fw affsprinp, respwlivtly.
This substance is not genotoxic with and without an exogenous metabolic aclivation system in
bacterial test and chramosomal aberration teslkr I&W
TOTM groduces the same spectrum of mcqhalr~gical and biochemical change in the rat Iiver as
DEHP. ‘TOI’M, however, was much ltss potent in ils actian, with a dietary level of 2.0%,
causing less peruxisomc proliferation andperoxisome-associated enzyme induction Ihan 0.67%
DEW. AISO, the Icvd ofpwoxisome induction in rats given ToThf is k-s than in those
receiving a metabolically eyuivalenl dose of 2-cthylhexanul, lktherrnore, on n molar basis,
cffecls were lower than with DEHP. An effect of MEHI’, a mctabvlile of DISHP, was not seen
with TOTM. PC British Industrial biolcq$cal Research Associalion (1985), EpA
OT$O510637j1985), JOHN R. HODGSC?N. (1987) ]
IO addition, recently studies have determined that rodents (rats) are susceptible ITernxjsome
proliferation. After all, these results suggest that the effect of DEHP on ljver are markedly
different btwtrn ather sptcics (marmosets) and roden& (rats). jkbimasa Kurarti CI a].
(19SS)] Therefore, DEHP was downgraded from Group ZB to Group 3 by the MC
Manugraphs Working Grwp. (February 2000) Group 3 is ” cannot be classified as to its
carcinogeniciry to humad’.
4. Hazards to the Environment
4.1 Aquatic Efkcts
TOTNl has 10 be considered as weakly toxic against aqualic organisms. Aquatic effects were
tested and results 8rc summarized in TabItS. As the Iowe~l acute and chronic toxici[y data, EC,
(rKQ mg-X. ,7&r) of Selenasfwm cupriccv-~urrrm ATCC22662 and NOEC (55.1, m& - 2lday)
6f Daphnia magna were adopted, respectively
Table 5. Summary of t4I’eci.s of TOTM un ayuutic orpsnisms
Organism
Algae
Tbt durslion Result (mg/L) Rekrence
Sele?lasIru?Tl 72hr EC, >I00 Et%, Japan
captlcornutum
~TCZ22662
h w r t&m tes
NOEC> 100
Unphnia magna 24 hr EC, >18Cl EA, Japan
48 llr EC5, z=lSO
NOEC>3 80
48hr _._ . . -.-._-... __.. ---_-_
21 day
EC,, >l
E&U =39,1
NOECk55.6
ICI 1990 --l.l”a”.-.-..-
EA, Japan