Trimellitate Category; Revised Summaries - US Environmental ...

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6. References Id 27251-75-8 Date 13.12.2001 (1) Mackay, D., A. DiGuardo, S. Paterson and C. Cowan, EQC Model ver. 1 .Ol , 1997, available form the Emvironmental Centre, Trent Univ. Canada. (2) Meylan, M. Syracuse Research Corporation (1994-1999) Calculation program contained in EPIWIN (Esitmate ver. 3.04) available from SRC. (3) Wilson, A., (1996). Plasticizers - Selection, Applications and Implications. Rapra Review Reports 8:15-16.
7. Risk Assessment Id 27251-75-8 7.1 END POINT SUMMARY 7.2 HAZARD SUMMARY Chapter Remark Attached dot. Flag 13.12.2001 7.3 RISK ASSESSMENT II/II Date 13.12.2001 : Chapters 4 & 5 : Because of the similarity in chemical structure, the Panel believes that the toxicological properties of the substances in this category will be similar as well. Thus, the Panel considers that the data for the best tested member of this category, tris-2-(ethylhexyl) trimellitate (TOTM), also represents the potential for human and environmental effects of the other members of this category. TOTM has been sponsored under the OECD SIDS program through ICCA. A review of the available data for TOTM (see attached Table) indicates that all endpoints have been adequately addressed, and that TOTM exhibits a low order of toxicity. Due to their higher molecular weight and bulky side chains, the remaining members of this category are expected to demonstrate a lower order of toxicity than TOTM. This is supported by a similar structural-activity relationship observed with phthalate ester compounds, i.e., the higher molecular weight phthalates (ester side chains X7) are less active that the transitional phthalates (ester side chains C4-C6). Thus, the use of TOTM to represent the potential hazards of the other category members is a conservative position. : S-u-mmary of SIDS Information on <strong>Trimellitate</strong>sdoc : Critical study for SIDS endpoint
Page 1 and 2: IUCLID Data Set Existing Chemical :
Page 3 and 4: 1. General Information Id 3319-31-1
Page 5 and 6: 2. Physico-Chemical Data Id 3319-31
Page 7 and 8: 3. Environmental Fate and Pathways
Page 11 and 12: 5. Toxicity Id 3319-31-1 5.1 .I ACU
Page 13 and 14: 5. Toxicity Id 3319-31-1 Test condi
Page 15 and 16: 6. References Id 3319-31-1 (3) (4)
Page 19 and 20: 1. General Information Id 27251-75-
Page 23 and 24: c 3. Environmental Fate and Pathway
Page 25: 5. Toxicity Id 27251-75-8 51.1 ACUT
Page 29 and 30: ! 1. General Information Id 53894-2
Page 31 and 32: i 2. Physico-Chemical Data Id 53894
Page 35 and 36: - 4. Ecotoxicity 4.1 ACUTE/PROLONGE
Page 37 and 38: 6. References Id 53894-23-8 Date 15
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Page 47 and 48: 5. Toxicity Id 67989-23-5 5.1 .I AC
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Page 51 and 52: Summary of SIDS Information on Trim
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Page 55 and 56: 4.5.2 4.6.1 4.6.2 4,6.3 Ft!zT 5.1.1
Page 57 and 58: 1. IDENTITY IUPAC Name: CM Number:
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Page 67 and 68: TJZST SUBSTANCE . lden Lily: h R~ma
Page 69 and 70: l Idenlily: . Rcma rks: METHOD . Me
Page 71: DRAFT ENV,‘JM/EXCH(99)13 VAPOR PR
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CONCLUSIONS DATA QUALITY Mortality
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DRAFT EI’WJM/EXCHI[99)13 TIEST WE
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DATA QUMJTY . Rtliabilitie~: Khiscb
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DRAFT ENV/JM/EXCH(99)23 REsuLTs Nom
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TEST SUBSTANCE 1 Identity: Remarks:
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DRAFT’ ENV/JMIEXCH(99)13 c DATA Q
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DRAFf ENV/3M/EXCH(99)13 Nominal cxu
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ACUTE ORAL. TOXICITY DRAFT ENV/JM/E
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ACUTE IN-L4lA’~lON TOXJCJTY + Ide
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mST SUBSTANCE . Idcnlity: ~js(2-eth
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Diet - Wqne 15% Rabbit Rzltion and
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TEST SUBSTANCE l lden Lily: Tris(2-
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t - . KEFERENCES GENERAL REmRKS ~uu
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SENSIT~ ZATI ON TJ3T SUBSTANCE . Id
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I Iden tilyr . Rems rks: METHOD . l
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IZST SUBSTANCE I Edcntity: l Remark
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DRAFT ENV/JM/EXCH(99)13 Female Day
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1 Genotoxic clbttsr With metabolic
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IIRAn ENV/JMfiXW(99)13 GENETIC TOXI
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