Trimellitate Category; Revised Summaries - US Environmental ...
Trimellitate Category; Revised Summaries - US Environmental ...
Trimellitate Category; Revised Summaries - US Environmental ...
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7. Risk Assessment Id 67989-23-5<br />
7.1 END POINT SUMMARY<br />
7.2 HAZARD SUMMARY<br />
Chapter<br />
Remark<br />
Attached dot.<br />
Flag<br />
13.12.2001<br />
7.3 RISK ASSESSMENT<br />
Date 13.12.2001<br />
: Chapters 4 & 5<br />
: Because of the similarity in chemical structure, the Panel believes that the<br />
toxicological properties of the substances in this category will be similar as<br />
well. Thus, the Panel considers that the data for the best tested member of<br />
this category, tris-2-(ethylhexyl) trimellitate (TOTM), also represents the<br />
potential for human and environmental effects of the other members of this<br />
category.<br />
TOTM has been sponsored under the OECD SIDS program through ICCA.<br />
A review of the available data for TOTM (see attached Table) indicates that<br />
all endpoints have been adequately addressed, and that TOTM exhibits a<br />
low order of toxicity.<br />
Due to their higher molecular weight and bulky side chains, the remaining<br />
members of this category are expected to demonstrate a lower order of<br />
toxicity than TOTM. This is supported by a similar structural-activity<br />
relationship observed with phthalate ester compounds, i.e., the higher<br />
molecular weight phthalates (ester side chains >C7) are less active that the<br />
transitional phthalates (ester side chains C4-C6). Thus, the use of TOTM<br />
to represent the potential hazards of the other category members is a<br />
conservative position.<br />
: Z&mmary of -- SIDS ---.-- Information on <strong>Trimellitate</strong>sdoc<br />
: Critical study for SIDS endpoint