Trimellitate Category; Revised Summaries - US Environmental ...

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Tris(Zethylhexpl}bcnzene-1,2,4-trica~xylale
Source: Nuoplaz 6959
Purity: 98.2% (GCEID) 97.97G (HFLC)
impurities were detected at level than 0.1~O.S%, one bcingdi(Zethy~hexyl)
phthalate (DEHP).
Melhod: l3II3RA SUndard Operating Prcxcdurcs
Test type: Repeat Dose Toxicity
GLP: Ytrs
Ytar: 1984
Species: Rat
Strain: Fischer 344
Rouie of administration Oral
I’hses/concentrarion levels: O(O), 0.2{184), 1).67(650) and Z(182-5) 5% (mflg bwldayj
VhicIe: Rodent die1
Sex; Male & Female
Exposure period; 28 days
Prcqucncy o,P treatment: Once daily
Control group and trratmcnC:Dietary level 0% and reference ccunpund DEEP 0.67%.
I%st exposure olmmhn period:None
Duration of test: Males and females; for28 clays
Statistical methods: The contrai and TOTM treated groups were subject 10 analysis csf
variance, and if this was signjfitiant the treated groups were c-ompanzd with
the contio~s using the Least Significant DiffCrencc test.
The controls and DEHP groups wex compared using 8 two-tail& pooled
student t test wilh WelcHs correction. In ssll cased a probability levei of
P4l.05 was taken to indicate statistical significance.
Study Design: Vehick DieI
SmcBi~e gm.p and mwws ~hsy were crbded: None
Clinical obsmurionsper$mwd and frquency:
Body wt. was recorded immediately prior 10 the first exposure and again for each
animal 1,3, 7,10, 14, 17, 21, 24, 27b days.
Twice each day the animals were observed in their cages forvariations in behaviour
or cmditiors and once weeklq’ a more dnailed examinaliun was made at rhe lime of
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