Trimellitate Category; Revised Summaries - US Environmental ...

EKE dw Esrimated Human EXP~H.IJ~ Lor dermal
Cdcr = 990 rngb~’ (Rate in product contacled by warker)
T = 0.01 cm ~hickncss of substance)
S = 84-O cm2 {Surface area of exposed skin) for hand
t = 0.0208 day/day (Exposure time per day ; lOmin#Hr, [lday = EHr) assumed)
W = 70 Kg (body weight)
2.2.2 cimsumcr expO,sur~
LJsuaIly, this substanCe has been already bknded to the compound asplasIicizer, so jt is not
exp.zcted that downsueam users CN consumers of electric wire industry may expose. to ihis
sllbstanca
3.HUMAN HEALTH HAZARIS
3.1 Effects on Human Health
3.1.1 Toxkokinetics and metabolism
I Absorption snd mctabnlism were sludied for TOTM(lK-labeled on the 2-carbon atom af 2-
elhylhex~~ group) mixed with COrnoil and administered: bygavagc io a single dose of IOU
mgjkg of bodg weight in 4 mele SDral$. About 75% of the dosewas cxcrclcd unchanged in the
feces, 16% in 1hc urine as tlEtaboliles and 1.956 was expired ;IS “CC+. Radioactiviiy was
excreted in the feces as unchanged ‘JJTM (85% of the fecal radioactivity), monc- and di(2-
elhylhexyl) trimellila1e~OTM and DOTM, respectively), and as unidentified polar metaboljles.
Metabolitcs in the urine were identified as ICOTM and melabolites of Zethylhexana1 less than
0.6% of the dose remsined in lhe tissues. Elimination &CO, was biphasic with half-lives af
4.3 and 31 hrs, and excrctian of radioactivity in the urinewas biphasic wirh half-lives of 3.4 hrs
and 42 bs. [Eastman Kodak Company]
3.1.2 Acute toxicity
.4cute toxicity data are mainly reported fur rat, mice and rabbits. We. cxwld find 12 acute
laxicity data for animaIs@ralCd), inhaIation{l), E’(2) and dcrmal(3)) 1~ data, and one(orQ
study @HIV, Japan (1996)) and two(oral and dermal) siudies PJuodex Inc.@9$1), Nuodex
Inc(1982c) > were conducted by the method of OECD TG and similar method to OEC~ TF,
respcclively.
‘The data, which NV? feel informalive to evaluarc the acute toxicily, are listed in Table 4.
t
79ble 4. Summary dcffccts ofTOTM on animals (Acute Toxicity)
RfJule Animals vsi rues Type References
Oral Rat
Rat
>2wo l-II&Q
>5wo ing,fk~bw
L&C
LT.&
MHW, Japan (1996)
Nuodex Inc.(lYX1)
Inhal a1 ion RM >2600 rng/k3 LC, Nuodex Inc.~1982b)
Dermal Rabbit >2 mlikg Lb Nuodex Inc(1982c)
Rabbit
>I90 m&kg bw LI& Tenneco Chemicals{1 981))
i I.P, Rat >3200 ttqy’kg bw LDSd Eastman Kadak [1983)
3 ~3200 m ‘kg bw LD, Eastman Kodak {I Y83
4