Trimellitate Category; Revised Summaries - US Environmental ...

Organ weighr chunges:
ac A? md qfdmkg
Mde: No dose-related change in all testedorgans.
Fen-de: Relative liver weight were slightly increased at 100 mg(kg dosing, but no
dose.related change. OLher organs, no significm change.
u$W rccoveringpwhk
M&S: At 1,000 m&kg dosing, relative kidne~cight were sligblly low,
Ft?Idt?: At 1,000 mg/kg dosing, absolotc and relalive adrenal weight w&relighlly
high.
But boih changes were consideredno related to dosing and recovering of lhis chemical.
Gross pathiugy and hisfupfhlogy:
of fhe end ofdmkg:
Afdes: C&wed patch/zone of lungs were observed 1 of 100 mg;kg, 2 of 300 n&kg
and 3 animals of 1,000 mg!kg dosing group. Also hypertrophy of the kiclney,
hypenraphy af parathyroid, and etc. were observed.
Amounts Of eosinophilic body in the kidney were slightly increased in dosing
group. 5111 all these changes were ccmsidered no related the: dosing and
recovering of lhischemka~ because tit? degree and rate of changes were same
of aI1 Ihe group included cont.roI.
Fern ales: Red patch/‘zone of thy mui dilated lumert of the uterus and etu. were observed.
But all these changes were considered no r&%-d the dosing and recovering of
tfiis chemical, because the degree and rate of changes were same of all the
group included control.
offer recuv ering periud:
M&s and Fwznh: NO dn?x-related significant change in all ksts.
CONCLIJSIONS
nATi QWALJTY
No test substance related changes were noted in terms of Clinical sigm, body weight. food
consumption, andhematology, blood chenicalexaminatioIs urinalysis, and pacbological
findings.
The NOEL for repeated dose toxicity is considered to be 3,000 mgIkg,!day for both saxes.
. Reliabilities: Klimisch tide: l-reliable without restriciions.
l Kernarks Iield for Dala ReliabiliLy:
Well conducted study , carried out by the Biosafety Research Center, Fcwd, Drugs and Pesticides
(An-pyo Centw), Japan
REJTERENCES
Toxicity l’esring Reports of EnvironmenIal Chemicals,vol.4(1996))
Ministry of Health & W-&are, Japon
GENERAL REMARKS
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