Trimellitate Category; Revised Summaries - US Environmental ...

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7. Risk Assessment Id 53894-23-8 7.1 END POINT SUMMARY 7.2 HAZARD SUMMARY Chapter Remark Attached dot. Flag 13.12.2001 7.3 RISK ASSESSMENT Date 15.03.2002 : Chapters 4 & 5 : Because of the similarity in chemical structure, the Panel believes that the toxicological properties of the substances in this category will be similar as well. Thus, the Panel considers that the data for the best tested member of this category, tris-2-(ethylhexyl) trimellitate (TOTM), also represents the potential for human and environmental effects of the other members of this category. TOTM has been sponsored under the OECD SIDS program through ICCA. A review of the available data for TOTM (see attached Table) indicates that all endpoints have been adequately addressed, and that TOTM exhibits a low order of toxicity. Due to their higher molecular weight and bulky side chains, the remaining members of this category are expected to demonstrate a lower order of toxicity than TOTM. This is supported by a similar structural-activity relationship observed with phthalate ester compounds, i.e., the higher molecular weight phthalates (ester side chains X7) are less active that the transitional phthalates (ester side chains C4-C6). Thus, the use of TOTM to represent the potential hazards of the other category members is a conservative position. : SurnmarypfS!PSl_nfp~~-~~ionn.Trlll~~l!itates.doc : Critical study for SIDS endpoint 1
IUCLID Data Set Existing Chemical : ID: 67989-23-5 CAS No. : 67989-23-5 EINECS Name : 1,2,4-Benzenetricarboxylic acid, decyl octyl ester EINECS No. : 268-007-3 TSCA Name : 1,2,4-Benzenetricarboxylic acid, decyl octyl ester Molecular Formula : C10H220.xC9H606.xC8H180 Producer Related Part Company Creation date Substance Related Part Company Creation date Memo Printing date Revision date Date of last Update Number of Pages : 11 Chapter (profile) Reliability (profile) Flags (profile) : ExxonMobil Biomedical Sciences Inc. : 02.11.2000 : ExxonMobil Biomedical Sciences Inc. : 02.11.2000 : ACC Phthalate Esters Panel HPV Testing Group : 13.12.2001 : 30.10.2001
Page 1 and 2: IUCLID Data Set Existing Chemical :
Page 3 and 4: 1. General Information Id 3319-31-1
Page 5 and 6: 2. Physico-Chemical Data Id 3319-31
Page 7 and 8: 3. Environmental Fate and Pathways
Page 11 and 12: 5. Toxicity Id 3319-31-1 5.1 .I ACU
Page 13 and 14: 5. Toxicity Id 3319-31-1 Test condi
Page 15 and 16: 6. References Id 3319-31-1 (3) (4)
Page 17 and 18: IUCLID Data Set Existing Chemical :
Page 19 and 20: 1. General Information Id 27251-75-
Page 23 and 24: c 3. Environmental Fate and Pathway
Page 25 and 26: 5. Toxicity Id 27251-75-8 51.1 ACUT
Page 27 and 28: 7. Risk Assessment Id 27251-75-8 7.
Page 29 and 30: ! 1. General Information Id 53894-2
Page 31 and 32: i 2. Physico-Chemical Data Id 53894
Page 35 and 36: - 4. Ecotoxicity 4.1 ACUTE/PROLONGE
Page 37: 6. References Id 53894-23-8 Date 15
Page 41 and 42: 1. General Information Id 67989-23-
Page 47 and 48: 5. Toxicity Id 67989-23-5 5.1 .I AC
Page 49 and 50: 7. Risk Assessment Id 67989-23-5 7.
Page 51 and 52: Summary of SIDS Information on Trim
Page 53 and 54: 3319311S~AP910.doc I ll I The Macka
Page 55 and 56: 4.5.2 4.6.1 4.6.2 4,6.3 Ft!zT 5.1.1
Page 57 and 58: 1. IDENTITY IUPAC Name: CM Number:
Page 59 and 60: EKE dw Esrimated Human EXP~H.IJ~ Lo
Page 61 and 62: Chromosomal aberralion lest by OECD
Page 63 and 64: I Fidl __-__________. - . .._. -..-
Page 65 and 66: Eastman Kodak. Absorption sncl melA
Page 67 and 68: TJZST SUBSTANCE . lden Lily: h R~ma
Page 69 and 70: l Idenlily: . Rcma rks: METHOD . Me
Page 71: DRAFT ENV,‘JM/EXCH(99)13 VAPOR PR
Page 74 and 75: I Rcmnrks: -. _ - - -
Page 76: --. TEST SUTSTANCE + Tdcn tily; . I
Page 80 and 81: 4 Kelia bilities: Key sludy l Remar
Page 83 and 84: w + l + + l + + l + Method: VP@: GL
Page 85: --. - ,-.-.. .----_ -. -_ l Remarks
Page 88 and 89:
CONCLUSIONS DATA QUALITY Mortality
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DRAFT EI’WJM/EXCHI[99)13 TIEST WE
Page 92 and 93:
DATA QUMJTY . Rtliabilitie~: Khiscb
Page 94 and 95:
DRAFT ENV/JM/EXCH(99)23 REsuLTs Nom
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TEST SUBSTANCE 1 Identity: Remarks:
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DRAFT’ ENV/JMIEXCH(99)13 c DATA Q
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DRAFf ENV/3M/EXCH(99)13 Nominal cxu
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ACUTE ORAL. TOXICITY DRAFT ENV/JM/E
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ACUTE IN-L4lA’~lON TOXJCJTY + Ide
Page 107 and 108:
mST SUBSTANCE . Idcnlity: ~js(2-eth
Page 109 and 110:
Diet - Wqne 15% Rabbit Rzltion and
Page 111 and 112:
TEST SUBSTANCE l lden Lily: Tris(2-
Page 113 and 114:
t - . KEFERENCES GENERAL REmRKS ~uu
Page 115 and 116:
SENSIT~ ZATI ON TJ3T SUBSTANCE . Id
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I Iden tilyr . Rems rks: METHOD . l
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increased in the TOTM and DEEP trea
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IZST SUBSTANCE I Edcntity: l Remark
Page 123 and 124:
Organ weighr chunges: ac A? md qfdm
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.l_.“. _.,“^---“~~, RESULTS P
Page 127 and 128:
JDJ-LGFI’ EJWJM/EXC.X(99)13 No. o
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DRAFT ENV/JM/EXCH(99)13 Female Day
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1 Genotoxic clbttsr With metabolic
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IIRAn ENV/JMfiXW(99)13 GENETIC TOXI
Page 135 and 136:
air side air-water hfl’C 5 soil a
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