Trimellitate Category; Revised Summaries - US Environmental ...

mST SUBSTANCE
. Idcnlity: ~js(2-ethylhexyl}benzene-1,2,4-tricarboxyInte
l Remnrks: Sburce: Nouplax 6959: Batch No. 39049
Purity: 93.95%
DRAFT ENWM,‘EXCH(99)13
. Method! Procedure set forth in the Federal Insecticide, Fungicide, andlodenticjde
Act (RFRA)
. GLP: Yes
. Year: 1981
l Species: Rabbits
I Strain: New Zealand albino white rabhi&
. Doseshw.entratian l~:vcls: 2.0 rnL/kg
. Sex: Male W Female
. Post exposure rr,bservPtion periud:Two weeks.
. Ratistical mttbods: Nor applicable because of no latalizy.
REMARKS PIELL) FOi? TEST C~NDJTICWJ
RESULTS
Test Subjects
Study Design: PrucedurPr: 24 hours prior to treatment the hair on the back of each rabbit
was clipped SO as to expose approxjmately 10% of ihc: hndy surface 3~3.
Before dosing, epidermal abrasions were made longitudinally CWCY rhe
exposure area. The abrasions were sufficiently deep to penetrate the
stratum cOmeUrn but not SCI deep as 10 cause bleeding.
A dosage was applied to the exposure area. A 2 x 2-inch gauze pad was
placed on the exposure area to prevent seepage of the compound frcsm 1h.e
area. Each animal was then wrapped with a rubber dam. After 24 hour of
exposure, rhe rubber dam anrj gauze pad were removed, and the exposure
area was wiped to remove any remaining tat material.
Satellite groups rind reu.su~ Lhsy wwe added; Acme
Chid obseuv~‘ons perfot-md andfrieguencp;
After the exposure, all animals were observed daily for 14 days for clinical
signs of toxicity. A gross ntcrapsy was performed an all animals at the end
of the 14 day observation period.
I LD,,: MaIe : > 2.0 mukg
Female : S. 2.p mL/kg
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