Trimellitate Category; Revised Summaries - US Environmental ...

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5. Toxicity Id 53894-23-8
5.1 .I ACUTE ORAL TOXICITY
5.4
5.5
5.6
5.8
5.9
Type
Species
Strain
Sex
Number of animals
Vehicle
Value
Method
Year
GLP
Test substance
Remark
Test condition
Test substance
Conclusion
Reliability
Flag
28.12.2000
REPEATED DOSE TOXICITY
GENETIC TOXICITY ‘IN VITRO‘
GENETIC TOXICITY ‘IN VITRO‘
TOXICITY TO REPRODUCTION
DEVELOPMENTAL TOXlClTY/TERATOGENlClTY
Date 15.032002
LD50
rat
Sprague-Dawley
male
20
no data
> 10000 mg/kg bw
other
1969
no
other TS
No rats died during the study. At the two higher dose levels, decreased
activity was observed one hour after dosing. Excessive urination and/or
diarrhea were initially observed but decreased by 48 hours (5000 mglkg
level) or by Day 5 (10,000 mg/kg level).
Immediately following a 3-4 hour fasting period, animals were administered
the test compound at doses of 417, 1450, 5000 and 10000 mg/kg of body
weight. Observations were recorded immediately after dosing, then at I, 4
and 24 hours; and once daily thereafter for 14 days. Gross necropsies
were conducted on all animals that were sacrificed at the termination of the
study.
1,2,4-benzenetricarboxylic acid, triisononyl ester (triisononyl phthalate)
Under the conditions of this study, the test material has a low order of
acute oral toxicity.
(2) valid with restrictions
Critical study for SIDS endpoint
(1)