Trimellitate Category; Revised Summaries - US Environmental ...

IZST SUBSTANCE
I Edcntity:
l Remarks:
METHOD
Mci hod:
Test type:
GLP:
Yt3r:
Spedcs:
Strain:
Route of rdministration
Tris(2-e~ylhexyl)benzene-1,2,4-~~~a~oxylale
Source: Daihachi Kagaku Kogyo Co., Ltd. tit. No. N-60601
Purity: >!W.O% Kept at room temperature in a dark place until USC.
Guidelines for B-day Repeated Dose Toxicity Testing of Chemicals
(Japan)
Repeat Isose Toxicity
Yes
1996
Rat
clj :CD(SD)
Or31
Doaw’conctntration levels; O(vehicIe) 100, 300 and 1,000 mg.&g!day
VdliCk Corn oil
Sex: Male & Female
Exposure period: 28 days
Frequency 0P treatment; Once daily
Control pup md Irestment:Vehicle {corn oil)
post txpos~re abservatiou period:2 weeks for 0 and 1,000 mg/kg/day dose,
Duration Of test: Males and females; for28 days
Statistical methods: Bartlett’s test, Dunnett’s te.sl or Kruskal-Wallis test dependingon wherher
or not the data were nonhomogeneous or homogeneous.
Fisher ‘s test for the patiological resdt, Jon&he&s test for the
correlaiion of dasagc
Study Design: Vehick CDm oil
Su.telZife groups and r~mtms they were added: None
CXnicuI olbsenl&~ns per$v$rted andj%quenq:
Body wt. was rEcorded immebialel)I prior to the first exp&ure and again for ea&
animal every week
I-lematdogic parameters urnere evaluated for each animal. Bloockamples Tar ihe
hematnlogic determinations were taken fronabdominal anery in ~~1s after 16 hr fast.
Clinical chemistry analyses were performed an serum silmples from each animal.
Urinalyses were performed for each rat. Urine samples were collected from each 1-31
on the day priDs to scheduled Lermhaljon.