Trimellitate Category; Revised Summaries - US Environmental ...

DRAFT ENWJMtEXCH(99)13
REXJLTS
c NOAEL
Organ weiphr: brain, liver, kidney, spieen,akenal, spemxq (male) and ovary
(females) kx each ank~al.
Micruscnpic: heart, liver, kidneys,spleen, adr~~al~~d hone marrow from rats in the
control and higb-expcwre groups aad kidney from all dosqe. male.
Male: >l,OOO mg,4&day
Female: > 1,000 mgikg/dsy
REMARKS FIELD FOR lW%Jt’JT$.
Rudy weight: The mean. body weight of ~realmenl groups of raLc h,r males and fem4eslot
Significantly JifIeren~ Irom conlrols at any time during the Course of the study.
j”ood/~a~ conr~n~~W;No Eignifican~Iy different from contr01S at any time during dosing and
recoveringperiod for both sexes.
Clinical signs : No unusual clinical obw-vatians during the study.
M&S: No dose-r&red change in gen;reral clinical signs.
Femaies;
Hi3e~ofag)l:
at the and of dmirq
No dose-r&led change in general cliniCa sip-&.
M&s and~emnf&: No dose-related sigrGfiCIfTlt cfimges i&emato@&y.
ajhw recovehg
In the blood clotting testy prothrombin times for males were slightly extended, bu1
they were cmxidtred within the physiaiogical change. Far females, no significant
changes in alI test.
period
MOILS: In hematology, hemoglobin amounts for males at ‘IUOOmgkg dosing were slightly
FtYHUh?s:
increased: but they were oonsidered within the p~ysialogical change. In the blood
clotting test, no significant changes in all tests.
No significant change in ail tests.
Bivchm :
ut the end ufduting
I
j
M&S: No dnse-related significant adverse tre;fltment-related effect in clinical chemistry.
Fe??loles: Al 300, and 1,01)0 mg/kg dosing, chlorine contents were hv,
qler recovering period
MUf#S: At 1,000 n&kg dosing, potassium contents were slightly high.
Ftwiuies: At 1,000 m&Xg dosing, GQT were slightly high.
But both changes were considered to be no meaning, bccux
were not recognised
at the end of treatment these changes
Urindysis :
ut the end ofdosing
M&sand ~w&s: Al 1,000 mg@ dosing, same of rats (bath sexes), amounts of urinary increased,
bul the mean urinary spccificgravity values in the 1,CJoO m&/kg dosing gJnUp
was ntx significant change from cc~ol
cpr recov wing period:
group.
/W&S rind Females: i% dose-relakd significant change in aI1 ksts.
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