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Cover ThesisproET-1; 212 amino acids). After removal of the signalsequence, it is further proteolytically processed at specificbasic residues leading to the production of bigET-1 (38amino acids). ET-1 is finally excised from big ET-1 by theaction of endothelin-coverting enzyme [10] . In the presentstudy, we determined plasma proET-1 in septic patients.The results showed that proET-1 levels in the unimprovedgroup were significantly higher than those in the healinggroup (p
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