Suppose that event A will occur <strong>in</strong> that experiment with probabilityP(A/B i ) if hypo<strong>the</strong>sis B i is <strong>in</strong>deed correct. After calculat<strong>in</strong>g P(B i /A)accord<strong>in</strong>g to that formula, we will obta<strong>in</strong> new estimates <strong>of</strong> <strong>the</strong>likelihood <strong>of</strong> <strong>the</strong> various hypo<strong>the</strong>ses.Modern probability <strong>the</strong>ory considers subjective probability as aconcept <strong>of</strong> magic 3 <strong>and</strong> only <strong>the</strong> term<strong>in</strong>ology is preserved accord<strong>in</strong>g towhich probabilities P(B 1 ), P(B 2 ), ..., P(B n ) are called prior, <strong>and</strong>P(B 1 /A), P(B 2 /A), ..., P(B n /A), posterior. But magic should be treatedcarefully: <strong>the</strong>re exists an important scientific doma<strong>in</strong> where <strong>the</strong>mentioned magical consideration is revived <strong>in</strong> an undoubtedlyscientific manner, <strong>the</strong> doma<strong>in</strong> <strong>of</strong> mach<strong>in</strong>e diagnostics.Suppose that a certa<strong>in</strong> hospital admits patients suffer<strong>in</strong>g fromdiseases B 1 , B 2 , ..., B n . The prior probabilities P(B 1 ), P(B 2 ), ..., P(B n )are <strong>in</strong>terpreted as frequencies <strong>of</strong> <strong>the</strong> correspond<strong>in</strong>g diseases. Event Ashould be understood here as <strong>the</strong> totality <strong>of</strong> <strong>the</strong> results <strong>of</strong> a diagnosticexam<strong>in</strong>ation <strong>of</strong> a patient. Posterior probabilities P(B 1 /A), P(B 2 /A), ...,P(B n /A) <strong>of</strong>fer some objective method <strong>of</strong> summ<strong>in</strong>g <strong>the</strong> <strong>in</strong>formationconta<strong>in</strong>ed <strong>in</strong> those exam<strong>in</strong>ations; objective does not necessarily meangood enough, but, anyway, not to be neglected beforeh<strong>and</strong>.The problem is only to f<strong>in</strong>d <strong>the</strong> probabilities P(A/B i ) needed forcalculat<strong>in</strong>g those posterior probabilities. It seems that for statisticallyderiv<strong>in</strong>g it, it suffices to look at its frequency as given <strong>in</strong> <strong>the</strong> casehistories <strong>of</strong> those suffer<strong>in</strong>g from B i , but here we encounter a veryunpleasant surprise: A is <strong>the</strong> result <strong>of</strong> a large number <strong>of</strong> exam<strong>in</strong>ations,a totality, so to say, <strong>of</strong> all <strong>the</strong> <strong>in</strong>dications revealable <strong>in</strong> a given patient<strong>and</strong> essential for diagnos<strong>in</strong>g him/her. Even <strong>the</strong> simplest exam<strong>in</strong>ation<strong>in</strong>cludes nowadays a number <strong>of</strong> analyses <strong>and</strong> <strong>in</strong>vestigations <strong>and</strong> partial<strong>in</strong>vestigations by many physicians <strong>of</strong> various specialities. It will not bean exaggeration at all to say that <strong>the</strong> amount <strong>of</strong> <strong>in</strong>formation is such that50 b<strong>in</strong>ary digits will be needed to write it down; actually, that numberwill perhaps only suffice after thoroughly select<strong>in</strong>g <strong>the</strong> <strong>in</strong>dicationsessential for <strong>the</strong> diagnosis.When adopt<strong>in</strong>g <strong>the</strong>se 50, we will have 2 50 ≈ 10 15 various possiblevalues <strong>of</strong> A. Suppose that previous statistics collected data on 10 4patients, <strong>the</strong>n, <strong>in</strong> <strong>the</strong> mean, 10 −11 observations will be available foreach possible value <strong>of</strong> A. Practically this means that an overwhelm<strong>in</strong>gmajority <strong>of</strong> <strong>the</strong>se values are not covered by any observations, almosteach new patient will provide a previously unknown result <strong>of</strong>exam<strong>in</strong>ation <strong>and</strong> it will be absolutely impossible to determ<strong>in</strong>e directly<strong>the</strong> probability P(A/B i ).Generally speak<strong>in</strong>g, <strong>in</strong> practical statistical <strong>in</strong>vestigations, whendesir<strong>in</strong>g to consider at once many factors <strong>and</strong> connections between<strong>the</strong>m, we usually f<strong>in</strong>d ourselves <strong>in</strong> a bl<strong>in</strong>d alley. Classify<strong>in</strong>g statisticalmaterial accord<strong>in</strong>g to several <strong>in</strong>dices very soon provides groups <strong>of</strong> oneobservation, <strong>and</strong> it is not known what to do with <strong>the</strong>m. Then, <strong>the</strong>Bayes <strong>the</strong>orem be<strong>in</strong>g ma<strong>the</strong>matically trivial naturally can not by itselfprovide any practical result. Never<strong>the</strong>less, consideration <strong>of</strong> manyfactors <strong>in</strong> medic<strong>in</strong>e is possible. There are contributions whose resultsare difficult to doubt, but it is premature to describe <strong>the</strong>m for <strong>the</strong>general reader. One <strong>of</strong> <strong>the</strong> possibilities here is connected with apply<strong>in</strong>g<strong>the</strong> concept <strong>of</strong> <strong>in</strong>dependence whose formulation we will now provide.18
2.3. Independence. When desir<strong>in</strong>g to consider <strong>the</strong> completestochastic characteristic <strong>of</strong> events A 1 , A 2 , ..., A n , we will need to know<strong>the</strong> probabilities <strong>of</strong> every possible setP(C 1 , C 2 , ..., C n )where each C i can take two values, A i <strong>and</strong> Ai.It is not difficult tocalculate that 2 n probabilities are needed. This number <strong>in</strong>creases veryrapidly with n <strong>and</strong> <strong>the</strong> pert<strong>in</strong>ent possibilities <strong>of</strong> any experiment become<strong>in</strong>sufficient. We expect such stochastic models to be applicable only ifthat difficulty is somehow overcome <strong>and</strong> <strong>the</strong> ma<strong>in</strong> part is played hereby <strong>the</strong> concept <strong>of</strong> <strong>in</strong>dependence.Def<strong>in</strong>ition. Two events, A <strong>and</strong> B, are <strong>in</strong>dependent if <strong>the</strong> conditionalP(A/B) <strong>and</strong> unconditional probabilities co<strong>in</strong>cide:P( AB)P( A / B) = P( A) or P( AB) P( A) P( B).P( B )= =For n events A 1 , A 2 , ..., A n <strong>in</strong>dependence is def<strong>in</strong>ed by equalityP(C 1 C 2 , ..., C n ) = P(C 1 ) P(C 2 ) ... P(C n ) (2.4)where each C i can take values A i <strong>and</strong> Ai.S<strong>in</strong>ce P( Ai) = 1 – P(A i ), <strong>the</strong>probabilities for <strong>in</strong>dependent events can be given by only n valuesP(A 1 ), P(A 2 ), ..., P(A n ).Independent events do exist; <strong>the</strong>y are realized <strong>in</strong> experiments carriedout <strong>in</strong>dependently one from ano<strong>the</strong>r (<strong>in</strong> <strong>the</strong> usual physical mean<strong>in</strong>g). Atextbook on <strong>the</strong> <strong>the</strong>ory <strong>of</strong> probability should show <strong>the</strong> reader how <strong>the</strong>correspond<strong>in</strong>g space <strong>of</strong> elementary events is constructed here, but thisbooklet is not a textbook. I have provided a sufficiently detailedexposition <strong>of</strong> <strong>the</strong> most essential notions <strong>of</strong> that <strong>the</strong>ory so as to showhow it is done, briefly <strong>and</strong> conveniently (one concept, one axiom, onedef<strong>in</strong>ition) <strong>in</strong> <strong>the</strong> set-<strong>the</strong>oretic language. The fur<strong>the</strong>r development isalso <strong>of</strong>fered briefly <strong>and</strong> conveniently, but from <strong>the</strong> textbook style I amturn<strong>in</strong>g to <strong>the</strong> style <strong>of</strong> a summary.2.4. R<strong>and</strong>om variables. Def<strong>in</strong>ition. A r<strong>and</strong>om variable is a functiondef<strong>in</strong>ed on a set <strong>of</strong> elementary events. They are usually denoted byGreek letters ξ, η, ζ etc. When desir<strong>in</strong>g to <strong>in</strong>clude <strong>the</strong> argumentω ⊂ Ω , we write ξ(ω), η(ω), ζ(ω) etc.A set <strong>of</strong> possible values a 1 , a 2 , ..., a n , ... <strong>of</strong> events, all <strong>of</strong> <strong>the</strong>mdifferent,{ω: ω ⊂ Ω , ξ(ω) = a i } = {ξ= a i }is connected with each r<strong>and</strong>om variable ξ = ξ(ω), as well asprobabilities∑P{ξ = a } = P(ω) = p , ω:ξ(ω) = a .i i i19
- Page 1 and 2: Studies in the History of Statistic
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usually very little of them. Indeed
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This is the celebrated model of aut
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applications of the theory of stoch
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achieved by differentiating because
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answering that question is extremel
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IIIV. N. TutubalinThe Boundaries of
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periodograms. It occurred that work
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at point x = 1. However, preceding
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He concludes that since the action
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The verification of the truth of a
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In the purely scientific sense this
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ought to learn at once the simple t
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the material world science had inde
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values of (2.1) realized in the n e
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*several dozen. The totality µ ica
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Mendelian laws. It is not sufficien
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example, the problem of the objecti
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a linear function is not restricted
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258 - 82 - 176 cases or 68.5% of al
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or, for discrete observations,IT(ω
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What objections can be made? First,
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eliability and queuing are known to
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Kolman E. (1939 Russian), Perversio
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measurement is provided. Recently,
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which means that sooner or later th
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The foundations of the Mises approa
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A rather subtle arsenal is develope
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4.3. General remarks on §§ 4.1 an
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BibliographyAlimov Yu. I. (1976, 19
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processes are now going on in the s
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obtaining a deviation from the theo
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VIOscar SheyninOn the Bernoulli Law