Aging Aging

HPRT Mutational Spectrum 1973. Edwards, A., Voss, H., Rice, P., Civitello, A., Stegeman, J., Schwager, C., Zimmerman,J., Erfle, H., Caskey, C. T., and Ansorge, W. (1990) Automated DNAsequencing of the human hprt locus. Genomics 6, 593–608.4. Cariello, N. F. (1994) Software for the analysis of mutations at the human hprtgene. Mutat. Res. 312, 173–185 (database updated 1996)5. Gibbs, R. A., Nguyen, P. N., Edwards, A., Civitello, A. B., and Caskey, C. T. (1990)Multiplex DNA deletion detection and exon sequencing of the hypoxanthinephosphoribosyltransferase gene in Lesch-Nyhan families. Genomics 7, 235–244.6. Albertini, R. J., O’Neill, J. P., Nicklas, J. A., Heintz, N. H., and Kelleher, P. C.(1985) Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistantT lymphocytes. Nature 316, 369–271.7. Österholm, A.-M., Fält, S., Lambert, B., and Hou, S.-M. (1995) Classification ofmutations at the human hprt-locus in T-lymphocytes of bus maintenance workersby multiplex-PCR and reverse transcriptase-PCR analysis. Carcinogenesis 16,1909–1912.8. Österholm, A.-M. and Hou, S.-M. (1998) Splicing mutations at the hprt locus inhuman T-lymphocytes in vivo. Environ. Mol. Mutagenesis 32, 25–32.9. Podlutsky, A., Österholm, A.-M., Hou, S.-M., Hofmaier, A., and Lambert, B. (1997)Spectrum of point mutations in the coding region of the hypoxantine phosphoribosyltransferase (hprt) gene in human T-lymphocytes in vivo. Carcinogenesis 19,557–566.10. Yang, J. L, Maher, V. M., and McCormick, J. J. (1989) Amplification and directnucleotide sequencing of cDNA from the lysate of low numbers of diploid humancells. Gene 83, 347–354.11. Fuscoe, J. C., Zimmerman, L. J., Harrington-Brock, K., and Moore, M. M. (1992)Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes.Mutat. Res. 283, 255–262.12. Steen, A.-M., Sahlén, S., Hou, S.-M., and Lambert, B. (1993) Hprt-activities andRNA phenotypes in 6-thioguanine resistant human T-lymphocytes. Mutat. Res. 286,209–215.13. Yang, T. P., Patel, P. I., Chinault, A. C., Stout, J. T., Jackson, L. G., Hildebrand, B.M., and Caskey, C. T. (1984) Molecular evidence for new mutation at the hprt locusin Lesch–Nyhan patients. Nature 310, 412–414.14. Hou, S.-M., Lambert, B., and Hemminki, K. (1995) Relationship between hprtmutant frequency, aromatic DNA adducts and genotypes for GSTM1 and NAT2 inbus maintenance workers. Carcinogenesis 16, 1913–1917.15. de Boer, J. G., Curry, J. D., and Glickman, B. W. (1993) A fast and simple methodto determine the clonal relationship among human T-cell lymphocytes. Mutat. Res.288, 173–180.16. Bourguin, A., Tung, R., Galili, N., and Sklar, J. (1990) Rapid, nonradioactive detectionof clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Proc.Natl. Acad. Sci. USA 87, 8536–8540.17. Bastlova, T. and Podlutsky, A. (1996) Molecular analysis of styrene oxide-inducedhprt mutation in human T-lymphocytes. Mutagenesis 11, 581–591.