Aging Aging

Fibroblast Model for Cell Senescence Studies 4747. Wheaton, K., Atadja, P., and Riabowol, K. (1996) Regulation of transcription factoractivity during cellular aging. Biochem. Cell Biol. 74, 523–534.48. Hara, E., Uzman, J. A., Dimri, G. P., Nehlin, J. O., Testori, A., and Campisi, J.(1996) The helix–loop–helix protein Id-1 and a retinoblastoma protein bindingmutant of SV40 T antigen synergize to reactivate DNA synthesis in senescenthuman fibroblasts. Dev. Genet. 18, 161–172.49. Gerhard, G. S., Phillips, P. D., and Cristofalo, V. J. (1991) EGF- and PDGF-stimulatedphosphorylation in young and senescent WI-38 cells. Exp. Cell Res. 193, 87–92.50. Phillips, P. D., Kuhnle, E., and Cristofalo, V. J. (1983) 125 I-EGF binding activityis stable throughout the replicative life-span of WI-38 cells. J. Cell. Physiol.114, 311–316.51. Phillips, P. D., Pignolo, R. J., and Cristofalo, V. J. (1987) Insulin-like growth factor-I:specific binding to high and low affinity sites and mitogenic action throughout the lifespan of WI-38 cells. J. Cell. Physiol. 133, 135–143.52. Ferber, A., Chang, C., Sell, C., Ptasznik, A., Cristofalo, V. J., Hubbard, K., Ozer, H.L., Adamo, M., Roberts, C. T., Jr., LeRoith, D. (1993) Failure of senescent humanfibroblasts to express the insulin-like growth factor-1 gene. J. Biol. Chem. 268,17,883–17,888.53. Brooks-Frederich, K. M., Cianciarulo, F. L., Rittling, S. R., and Cristofalo, V. J. (1993)Cell cycle-dependent regulation of Ca 2+ in young and senescent WI-38 cells. Exp. CellRes. 205, 412–415.54. Allen, R. G., Tresini, M., Keogh, B. P., Doggett, D. L., and Cristofalo, V. J. (1999)Differences in electron transport potential antioxidant defenses and oxidant generationin young and senescent fetal lung fibroblasts (WI-38). J. Cell. Physiol. 180, 114–122.55. Blumenthal, E. J., Miller, A. C., Stein, G. H., and Malkinson, A. M. (1993) Serine/threonine protein kinases and calcium-dependent protease in senescent IMR-90 fibroblasts.Mech. Ageing Dev. 72, 13–24.56. Venable, M. E., Blobe, G. C., and Obeid, L. M. (1994) Identification of a defect in thephospholipase D/diacylglycerol pathway in cellular senescence. J. Biol. Chem. 269,26,040–26,044.57. Cook, S. J. and McCormick, F. (1996) Kinetic and biochemical correlation betweensustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation andlysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem. J. 320,237–245.58. Lavoie, J. N., G, L. A., Brunet, A., Muller, R., and Pouyssegur, J. (1996) Cyclin D1expression is regulated positively by the p42/p44MAPK and negatively by thep38/HOGMAPK pathway. J. Biol. Chem. 271, 20608–20616.59. Meloche, S. (1995) Cell cycle reentry of mammalian fibroblasts is accompaniedby the sustained activation of p44 mapk and p42 mapk isoforms in the G 1 phase andtheir inactivation at the G 1 /S transition. J. Cell. Physiol. 163, 577–588.60. Walter, S. A., Guadagno, T. M., and Ferrell, J. E., Jr. (1997) Induction of aG 2 -phase arrest in Xenopus egg extracts by activation of p42 mitogen-activatedprotein kinase. Mol. Biol. Cell 8, 2157–2169.