Aging Aging

Genetically Engineered Mice 373locus YAC mice carrying human globin developmental genes. Proc. Natl. Acad.Sci. USA 12, 5655–5659.7. Lamb, B. T., Call, L. M., Slunt, H. H., Bardel, K. A., Lawler, A. M., Eckman, C. B.,Younkin, S. G., Holtz, G., Wagner, S. L., Price, D. L., Sisodia, S. S., and Gearhart,J. D. (1997) Altered metabolism of familial Alzheimer’s disease-linked amyl oidprecursor protein variants in yeast artificial chromosome transgenic mice. Hum.Mol. Genet. 9, 1535–1541.8. Palmiter, R. D., Sandgren, E. P., Avarbock, M. R., Allen, D. D., and Brinster, R. L.(1991) Heterologous introns can enhance expression of transgenes in mice. Proc.Natl. Acad. Sci. USA 2, 478–482.9. Valera, A., Solanes, G., Fernandez-Alvarez, J., Pujol, A., Ferrer, J., Asins, G., Gomis,R., and Bosch, F. (1994) Expression of GLUT-2 antisense RNA in beta cells oftransgenic mice leads to diabetes. J. Biol. Chem. 269, 28,543–28,546.10. Prockop, D. J., Kuivaniemi, H., and Tromp, G. (1994) Molecular basis of osteogenesisimprefecta and related bone disorders. Clin. Plast. Surg. 21, 7–13.11. Cockayne, D. A., Bodine, D. M., Cline, A., Nienhuis, A. W., and Dunbar, C. E.(1994) Transgenic mice expressing anti-sense interleukin-3 develop a B-celllymphoproliferative syndrome or neurologic disfunction. Blood 84, 2699–2710.12. Stec, I., Barden, N., Reul, J. M., and Holsboer, F. (1994) Dexamethosonenonsuppression in transgenic mice expressing antisense RNA to the glucocorticoidreceptor. J. Psychiatr. Res. 28, 1–5.13. Davis, B. M., Lewin, G. R., Mendell, L. M., and Jones, M. E. (1993) Altered expressionof nerve growth factor in the skin of transgenic mice leads to changes in responseto mechanical stimuli. Neuroscience 56, 789–792.14. Matsumoto, K., Kakidani, H., Takahashi, A., Nakagata, N., Anzai, M., Matsuzaki,Y., Takahashi, Y., Miyata, K., Utsumi, K., and Iritani, A. (1993) Growth retardationin rats whose growth hormone gene expression was suppressed by antisense RNAtransgene. Mol. Repro. Dev. 36, 53–58.15. Capecchi, M. R. (1989a) The new mouse genetics: altering the genome by genetargeting. Trends Genet. 5, 70–76.16. Capecchi, M. R. (1989b) Altering the genome by homologous recombination. Science244, 1288–1292.17. Abbondanzo, S. J., Gadi, I., and Stewart, C. L. (1993) Derivation of embryonicstem cell lines, in Methods in Enzymology (Wasserman, P. M. and DePamphilis, M.L., eds.), Academic Press, New York, pp. 803–823.18. Kagi, D., Ledermann, B., Burki, K. Seiler, P., Odermatt, B., Olsen, K. J., Podack, E. R.Zinkernagel, R. M., and Hengartner, H. (1994) Cytotoxicity mediated by T cells andnatural killer cells is greatly impaired in perform-deficient mice. Nature 369, 31–37.19. Kontgen, F., Suss, G., Stewart, C. L., Steinmetz, M., and Bluthman, H. (1993)Targeted disruption of the MIIIC class II Aa gene in C57BL/6 mice. Int. Immunol.5, 957–964.20. Nada, S., Yagi, T., Takeda, H., Tokunaga, T., Nakagawa, H., Ikawa, Y., Okada, M.,and Aizawa, S. (1993) Constitutive activity of src family kinases in mouse embryosthat lack Csk. Cell 73, 1125–1135.