Aging Aging

60 Pawelection, the VERUM Foundation, the Novartis Foundation for GerontologicalResearch, the ƒortüne Program of University of Tübingen Medical Faculty,and the European Commission (see http://www.medizin.uni-tuebingen.de/eucambis/).References1. Bach, F. H., Inouye, H., Hank, J. A., and Alter, B. J. (1979) Human T-lymphocyteclones reactive in primed lymphocyte typing and cytotoxicity. Nature 281,307–309.2. Pawelec, G. and Wernet, P. (1980) Restimulation properties of human alloreactivecloned T cell lines. Dissection of HLA-D-region alleles in population studies and infamily segregation analysis. Immunogenetics 11, 507–519.3. Morgan, D. A., Ruscetti, F. W., and Gallo, R. C. (1976) Selective in vitro growth ofT-lymphocytes from normal human bone marrows. Science 193, 1007–1008.4. Effros, R. B. and Walford, R. L. (1984) T cell cultures and the Hayflick limit. Hum.Immunol. 9, 49–65.5. Pawelec, G. (1985) Functions and changing activities of interleukin 2-dependenthuman T lymphocyte clones derived from sensitization in mixed leukocyte cultures,in T Cell Clones (von Boehmer, H. and Haas, W., eds.), Elsevier, Amsterdam,Holland, pp. 311–322.6. Johnson, J. P., Cianfriglia, M., Glasebrook, A. L. and Nabholz, M. (1982) Karyotypeevolution of cytolytic T cell lines, in Isolation, Characterisation, and Utilisationof T Lymphocyte Clones (Fathman, C. G., Fitch, F. W., eds.), Academic Press, NewYork, pp. 183–191.7. Kaltoft, K., Pedersen, C. B., Hansen, B. H., and Thestrup-Pedersen, K. (1995)Appearance of isochromosome 18q can be associated with in vitro immortalizationof human T lymphocytes. Cancer Genet. Cytogenet. 81, 13–16.8. Kahle, P., Wernet, P., Rehbein, A., Kumbier, I., and Pawelec, G. (1981) Cloning offunctional human T lymphocytes by limiting dilution: impact of feeder cells andinterleukin 2 sources on cloning efficiencies. Scand. J. Immunol. 4, 493–502.9. Pawelec, G., Schwuléra, U., Blaurock, M., Busch, F. W., Rehbein, A., Balko, I., andWernet, P. (1987) Relative cloning efficiencies and long-term propagation capacityfor T cell clones of highly purified natural interleukin 2 compared to recombinantinterleukin 2 in man. Immunobiology 174, 67–75.10. Effros, R. B. and Pawelec, G. (1997) Replicative senescence of T lymphocytes:does the Hayflick Limit lead to immune exhaustion? Immunol. Today 18, 450–454.11. Pohla, H., Adibzadeh, M., Buhring, H. J., Siegels-Hubenthal, P., Deikeler, T.,Owsianowsky, M., Schenk, A., Rehbein, A., Schlotz, E., Schaudt, K., and Pawelec,G. (1993) Evolution of a CD3 + CD4 + alpha/beta T-cell receptor + mature T-cell clonefrom CD3 - CD7 + sorted human bone marrow cells. Dev. Immunol. 3, 197–210.12. Preffer, F. I., Kim, C. W., Fischer, K. H., Sabga, E. M., Kradin, R. L., and Colvin, R.B. (1989) Identification of pre-T cells in human blood. Extrathymic differentiationof CD7 + CD3 - cells into CD3 + gamma/delta or alpha/beta + T cells. J. Exp. Med.170, 177–190.