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2008 Clinical Practice Guidelines - Canadian Diabetes Association

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<strong>2008</strong> CLINICAL PRACTICE GUIDELINES<br />

S80<br />

RECOMMENDATIONS<br />

1.A comprehensive healthy lifestyle intervention program<br />

(including a hypocaloric, nutritionally balanced diet, regular<br />

physical activity or exercise, and behavioural modification<br />

techniques) for overweight and obese people<br />

with, or at risk for diabetes, should be implemented to<br />

achieve and maintain a healthy body weight [Grade D,<br />

Consensus]. Members of the healthcare team should<br />

consider using a structured approach to providing<br />

advice and feedback on physical activity, healthy eating<br />

habits and weight loss [Grade C, Level 3 (31-34)].<br />

2. In overweight or obese adults with type 2 diabetes, a<br />

pharmacologic agent such as orlistat [Grade A, Level 1A<br />

(26)] or sibutramine [Grade B, Level 2 (37)] should be<br />

considered as an adjunct to lifestyle modifications to<br />

facilitate weight loss and improve glycemic control.<br />

3.Adults with class III obesity (BMI ≥40.0 kg/m 2 ) or class II<br />

obesity (BMI 35.0 to 39.9 kg/m 2 ) with other comorbidities<br />

may be considered for bariatric surgery when other<br />

lifestyle interventions are inadequate in achieving weight<br />

goals [Grade C, Level 3 (43)].<br />

OTHER RELEVANT GUIDELINES<br />

Physical Activity and <strong>Diabetes</strong>, p. S37<br />

Nutrition Therapy, p. S40<br />

RELATED WEBSITES<br />

Health Canada. <strong>Canadian</strong> <strong>Guidelines</strong> for Body Weight<br />

Classification in Adults. Quick Reference for Professionals.<br />

Available at: http://www.hc-sc.gc.ca/fn-an/alt_formats/<br />

hpfb-dgpsa/pdf/nutrition/cg_quick_ref-ldc_rapide_ref_e.pdf.<br />

Accessed September 1, <strong>2008</strong>.<br />

OBESITY CANADA GUIDELINES<br />

2006 <strong>Canadian</strong> <strong>Clinical</strong> <strong>Practice</strong> <strong>Guidelines</strong> on the<br />

Management and Prevention of Obesity in Adults and<br />

Children. Available at: http://www.cmaj.ca/cgi/content/<br />

full/176/8/S1/DC1. Accessed September 1, <strong>2008</strong>.<br />

REFERENCES<br />

1. UK Prospective <strong>Diabetes</strong> Study (UKPDS) Group. Intensive<br />

blood-glucose control with sulphonylureas or insulin compared<br />

with conventional treatment and risk of complications in<br />

patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:<br />

837-853.<br />

2. Ruderman N, Chisholm D, Pi-Sunyer X, et al.The metabolically<br />

obese, normal-weight individual revisited. <strong>Diabetes</strong>. 1998;<br />

47:699-713.<br />

3. Markovic TP, Jenkins AB, Campbell LV, et al.The determinants<br />

of glycemic responses to diet restriction and weight loss in obesity<br />

and NIDDM. <strong>Diabetes</strong> Care. 1998;21:687-694.<br />

4. Calle EE, Rodriguez C, Walker-Thurmond K, et al.<br />

Overweight, obesity, and mortality from cancer in a prospectively<br />

studied cohort of U.S. adults. N Engl J Med. 2003;<br />

348:1625-1638.<br />

5. Stevens J, Cai J, Pamuk ER, et al.The effect of age on the association<br />

between body-mass index and mortality. N Engl J Med.<br />

1998;338:1-7.<br />

6. Health Canada. <strong>Canadian</strong> <strong>Guidelines</strong> for Body Weight Classification<br />

in Adults. Ottawa, ON: Health Canada; 2003. Publication H49-<br />

179/2003E.<br />

7. Rabkin SW, Chen Y, Leiter L, et al. Risk factor correlates of body<br />

mass index. <strong>Canadian</strong> Heart Health Surveys Research Group.<br />

CMAJ. 1997;157(suppl 1):S26-S31.<br />

8. World Health Organization. Obesity: preventing and managing<br />

the global epidemic. Report of a WHO consultation. World<br />

Health Organ Tech Rep Ser. 2000;894:i-xii,1-253.<br />

9. Reeder BA, Senthilselvan A, Després JP, et al.The association of<br />

cardiovascular disease risk factors with abdominal obesity in<br />

Canada. <strong>Canadian</strong> Heart Health Surveys Research Group. CMAJ.<br />

1997;157(suppl 1):S39-S45.<br />

10. Després JP, Lemieux I, Prud’homme D. Treatment of obesity:<br />

need to focus on high risk abdominally obese patients. BMJ.<br />

2001;322:716-720.<br />

11. Expert Panel on Detection, Evaluation, and Treatment of High<br />

Blood Cholesterol in Adults. Executive Summary of The Third<br />

Report of The National Cholesterol Education Program (NCEP)<br />

Expert Panel on Detection, Evaluation, and Treatment of High<br />

Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA.<br />

2001;285:2486-2497.<br />

12. Grundy SM, Cleeman JI, Daniels SR, et al; American Heart<br />

<strong>Association</strong>; National Heart, Lung, and Blood Institute.<br />

Diagnosis and management of the metabolic syndrome: an<br />

American Heart <strong>Association</strong>/National Heart, Lung, and Blood<br />

Institute Scientific Statement. Circulation. 2005;112:2735-2752.<br />

13. International <strong>Diabetes</strong> Federation. The IDF Consensus Worldwide<br />

Definition of the Metabolic Syndrome. Brussels: IDF<br />

Communications; 2006. Available at: http://www.idf.org/<br />

web data/docs/IDF_Meta_def_final.pdf. Accessed September<br />

1, <strong>2008</strong>.<br />

14. Wing RR, Marcus MD, Epstein LH, et al.Type II diabetic subjects<br />

lose less weight than their overweight nondiabetic spouses.<br />

<strong>Diabetes</strong> Care. 1987;10:563-566.<br />

15. Dattilo AM, Kris-Etherton PM. Effects of weight reduction on<br />

blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr.<br />

1992;56:320-328.<br />

16. Goldstein DJ. Beneficial health effects of modest weight loss. Int<br />

J Obes Relat Metab Disord. 1992;16:397-415.<br />

17. Elmer PJ, Grimm R Jr, Laing B, et al. Lifestyle intervention:<br />

results of the Treatment of Mild Hypertension Study (TOMHS).<br />

Prev Med. 1995;24:378-388.<br />

18. Tuomilehto J, Lindström J, Eriksson JG, et al; Finnish <strong>Diabetes</strong><br />

Prevention Study Group. Prevention of type 2 diabetes mellitus<br />

by changes in lifestyle among subjects with impaired glucose tolerance.<br />

N Engl J Med. 2001;344:1343-1350.<br />

19. Knowler WC, Barrett-Connor E, Fowler SE, et al; <strong>Diabetes</strong><br />

Prevention Program Research Group. Reduction in the incidence<br />

of type 2 diabetes with lifestyle intervention or met-

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