Research Publications - College of Medicine and Health Science
Research Publications - College of Medicine and Health Science
Research Publications - College of Medicine and Health Science
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Department <strong>of</strong> Paediatrics<br />
58<br />
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knock out animal models that the stem cells<br />
may have a prominent role in the evolutionary<br />
transition <strong>of</strong> gastritis to Gastric cancer in<br />
certain H pylori infected individuals. This area<br />
has certainly opened up possibilities for us<br />
to investigate in our Pediatric patients with H<br />
pylori infections that undergo endoscopies <strong>and</strong><br />
biopsies to study H pylori using immunohistochemistry<br />
<strong>and</strong> electron microscopy. This study<br />
is already underway with collaborators from Al<br />
Ain Hospital, Tawam Hospital <strong>and</strong> the Department<br />
<strong>of</strong> Anatomy at FMHS.<br />
����������������������������<br />
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�������������������������������������������madi).<br />
A primary interest is exploring toxininduced<br />
apoptosis, particularly the “mitochondrial<br />
cell death pathway”. Cell types include<br />
human lymphocytes <strong>and</strong> mouse hepatocytes,<br />
cardiomyocytes <strong>and</strong> lungs. The toxins include<br />
aflatoxins B1, dactinomycin <strong>and</strong> doxorubicin.<br />
The principle analytical method is phosphorescence<br />
oxygen analyzer that measures cellular<br />
respiration (cellular mitochondrial oxygen<br />
consumption). Moreover, intracellular caspase<br />
activities are monitored on HPLC, using caspase<br />
substrates such as Ac-DEVD-AMC <strong>and</strong> Ac-DEVD-<br />
AFC.<br />
��������������������������������������������<br />
������������������������������������� We<br />
investigate the effects <strong>of</strong> various toxic agents<br />
(e.g., aflatoxins B1 <strong>and</strong> nanoparticles) on circulating<br />
fetal cells.<br />
������������������������������������������<br />
������������������������������� We investigate<br />
Con A hepatitis is associated with hepatocyte<br />
apoptosis. The animal models include wild-type<br />
(C57BL) <strong>and</strong> various knockout mice. Apoptosis<br />
is detected by cellular respiration <strong>and</strong> caspase<br />
activation.<br />
�������������������������������������<br />
�������������������������������������<br />
����������������������������������������<br />
���������������������������������������������mined<br />
for healthy adults, children <strong>and</strong> newborns<br />
(umbilical cord blood). Lymphocytes<br />
from patients with presumed impaired respiration<br />
are investigated. The aim <strong>of</strong> this project<br />
is to show feasibility <strong>of</strong> using the phosphores-<br />
cence oxygen analyzer as a screening tool for<br />
patients with defective oxidative phosphorylation.<br />
�����������<br />
���������������������������������������������tients<br />
with glucose-6-phosphate dehydrogenase<br />
(G6PD) deficiency (A.-K. Souid). Blood<br />
samples will be collected from patients with<br />
G6PD deficiency during <strong>and</strong> after acute hemolysis.<br />
The red blood cell thiols will be labeled with<br />
monobromobimane. The GS-bimane derivatives<br />
will be separated on HPLC <strong>and</strong> detected by<br />
fluorescence.<br />
������������������������������������������<br />
with alpha-thalassemia trait. (S. Denic <strong>and</strong><br />
A.-K. Souid).<br />
The aim <strong>of</strong> this project is to establish red blood<br />
cell reference values for UAE citizen.<br />
������������������������������������������ferentiate<br />
between iron deficiency <strong>and</strong> alpha<br />
thalassaemias in children with microcytosis<br />
������������������������������������������<br />
This study looked at the value <strong>of</strong> several RBC<br />
indices, calculated from available results on CBC<br />
<strong>of</strong> children with hypochromia <strong>and</strong>/or microcytosis,<br />
to predict alpha-thalassemia or iron<br />
deficiency, both being common conditions in<br />
children in the UAE. The results have important<br />
clinical implications to avoid unnecessary<br />
investigations <strong>and</strong> prevent inappropriate <strong>and</strong><br />
potentially harmful administration <strong>of</strong> iron supplementation.<br />
�������������������������������������<br />
��������������������������� has been reported<br />
<strong>and</strong> studied.<br />
������prevalence <strong>of</strong> food allergy in children in<br />
Al Ain has been established.<br />
������prevalence <strong>and</strong> types <strong>of</strong> primary immunodeficiency<br />
in the UAE is currently being<br />
studied.<br />
���������������atopic dermatitis <strong>and</strong> food sensitization<br />
in children is being planned.<br />
���������������������������������<br />
������������������������ The aim <strong>of</strong> this<br />
project is to describe the natural history <strong>of</strong> pediatric<br />
tracheotomy <strong>and</strong> its outcomes.<br />
������������������������������������tients<br />
with asthma. The aim <strong>of</strong> this project is to