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Research Publications - College of Medicine and Health Science

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Department <strong>of</strong> Paediatrics<br />

58<br />

������������������������������������������<br />

knock out animal models that the stem cells<br />

may have a prominent role in the evolutionary<br />

transition <strong>of</strong> gastritis to Gastric cancer in<br />

certain H pylori infected individuals. This area<br />

has certainly opened up possibilities for us<br />

to investigate in our Pediatric patients with H<br />

pylori infections that undergo endoscopies <strong>and</strong><br />

biopsies to study H pylori using immunohistochemistry<br />

<strong>and</strong> electron microscopy. This study<br />

is already underway with collaborators from Al<br />

Ain Hospital, Tawam Hospital <strong>and</strong> the Department<br />

<strong>of</strong> Anatomy at FMHS.<br />

����������������������������<br />

����������������������������������������<br />

�������������������������������������������madi).<br />

A primary interest is exploring toxininduced<br />

apoptosis, particularly the “mitochondrial<br />

cell death pathway”. Cell types include<br />

human lymphocytes <strong>and</strong> mouse hepatocytes,<br />

cardiomyocytes <strong>and</strong> lungs. The toxins include<br />

aflatoxins B1, dactinomycin <strong>and</strong> doxorubicin.<br />

The principle analytical method is phosphorescence<br />

oxygen analyzer that measures cellular<br />

respiration (cellular mitochondrial oxygen<br />

consumption). Moreover, intracellular caspase<br />

activities are monitored on HPLC, using caspase<br />

substrates such as Ac-DEVD-AMC <strong>and</strong> Ac-DEVD-<br />

AFC.<br />

��������������������������������������������<br />

������������������������������������� We<br />

investigate the effects <strong>of</strong> various toxic agents<br />

(e.g., aflatoxins B1 <strong>and</strong> nanoparticles) on circulating<br />

fetal cells.<br />

������������������������������������������<br />

������������������������������� We investigate<br />

Con A hepatitis is associated with hepatocyte<br />

apoptosis. The animal models include wild-type<br />

(C57BL) <strong>and</strong> various knockout mice. Apoptosis<br />

is detected by cellular respiration <strong>and</strong> caspase<br />

activation.<br />

�������������������������������������<br />

�������������������������������������<br />

����������������������������������������<br />

���������������������������������������������mined<br />

for healthy adults, children <strong>and</strong> newborns<br />

(umbilical cord blood). Lymphocytes<br />

from patients with presumed impaired respiration<br />

are investigated. The aim <strong>of</strong> this project<br />

is to show feasibility <strong>of</strong> using the phosphores-<br />

cence oxygen analyzer as a screening tool for<br />

patients with defective oxidative phosphorylation.<br />

�����������<br />

���������������������������������������������tients<br />

with glucose-6-phosphate dehydrogenase<br />

(G6PD) deficiency (A.-K. Souid). Blood<br />

samples will be collected from patients with<br />

G6PD deficiency during <strong>and</strong> after acute hemolysis.<br />

The red blood cell thiols will be labeled with<br />

monobromobimane. The GS-bimane derivatives<br />

will be separated on HPLC <strong>and</strong> detected by<br />

fluorescence.<br />

������������������������������������������<br />

with alpha-thalassemia trait. (S. Denic <strong>and</strong><br />

A.-K. Souid).<br />

The aim <strong>of</strong> this project is to establish red blood<br />

cell reference values for UAE citizen.<br />

������������������������������������������ferentiate<br />

between iron deficiency <strong>and</strong> alpha<br />

thalassaemias in children with microcytosis<br />

������������������������������������������<br />

This study looked at the value <strong>of</strong> several RBC<br />

indices, calculated from available results on CBC<br />

<strong>of</strong> children with hypochromia <strong>and</strong>/or microcytosis,<br />

to predict alpha-thalassemia or iron<br />

deficiency, both being common conditions in<br />

children in the UAE. The results have important<br />

clinical implications to avoid unnecessary<br />

investigations <strong>and</strong> prevent inappropriate <strong>and</strong><br />

potentially harmful administration <strong>of</strong> iron supplementation.<br />

�������������������������������������<br />

��������������������������� has been reported<br />

<strong>and</strong> studied.<br />

������prevalence <strong>of</strong> food allergy in children in<br />

Al Ain has been established.<br />

������prevalence <strong>and</strong> types <strong>of</strong> primary immunodeficiency<br />

in the UAE is currently being<br />

studied.<br />

���������������atopic dermatitis <strong>and</strong> food sensitization<br />

in children is being planned.<br />

���������������������������������<br />

������������������������ The aim <strong>of</strong> this<br />

project is to describe the natural history <strong>of</strong> pediatric<br />

tracheotomy <strong>and</strong> its outcomes.<br />

������������������������������������tients<br />

with asthma. The aim <strong>of</strong> this project is to

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