Vol. 5, n. 1, January-March 2009 1th International ... - Salute per tutti

Clinical and instrumental evaluation of the activity of a combined cosmetic treatment applied to stretchmarks
Ascorbic acid: vitamin C essential for the
organism: it stimulates the synthesis of interferon,
the carnitine biosynthesis and makes iron
absorption easier.
It can play an important role in stretchmark and
wound healing.
Colostrum H1: bovine colostrum coming
from breedings rigorously selected and certified,
which is collected within the first hour
from delivery (H1) in order to get the maximum
concentration of growth factors and cell
regeneration, as Fibroblast Growth Factor (FGF)
and Epithelial Growth Factor (EGF), lysozyme,
biotin (vitamin H) and cytokines.
Naturally rich in immunoglobulin (antibody Ig
G 1 ) and telomerase (cellular repair enzyme),
colostrum is not subject to chemical-physical
processes that can damage or inactivate its
essential and useful principles.
Colostrum H1 has a much higher concentration
of active factors than commercial colostrum,
which is generally collected within 24 hours after
d e l i v e ry. This produces an immediate cosmetic
e ffect, which is visible right from the first hours
and long-lasting. It also has a regenerating, re v italizing
and anti-age action on the skin.
Pari cream also contains Biovin and Sericin, as
well as Dispari cream.
escription of the study
D
Aim of this study was to evaluate clinically
and by non invasive instrumental evaluations
the activity of the combined cosmetic tre a tment,
Pari cre a m and Dispari cre a m, on stre t c hmarks.
Clinical and instrumental evaluations
w e re performed in basal condition and after 8
and 16 weeks of treatment. It was also aim of the
study to evaluate cosmetic acceptability by the
volunteers and products efficacy and tolerance
both by investigator and volunteers. The study
was planned as an open trial conducted by 1
c e n t re and one investigator. The two diff e re n t
p roducts were to be applied on alternative days.
Each included subject had to apply altern a t i v e l y
the study products on skin areas affected by
s t retchmarks once a day for a period of 16 weeks
with a light massage. The study foresaw 3 visits:
a basal visit (T0), an intermediate visit after eight
weeks (T8) and a final visit at the end of the
t reatment, after sixteen weeks (T16). The study
was started out on 24 informed, adult, healthy,
female volunteers (age range: 18-57 years,
m e a n = 40) affected by stretchmarks of recent or
old appearance. During the course of the study
one subject dropped for reasons not related to
the study. The volunteers signed a written
informed consent and accepted not to deviate
f rom their normal alimentary and life habits for
the month preceding the test and for the entire
duration of the study. Moreover unprotected sun
and UV light exposure were avoided. At basal
conditions (T0) during the clinical examination
the investigator assigned to each subject a skin
a rea, affected by stretchmarks, to be treated and
to be submitted to clinical and instrumental
evaluations. Selected skin area was kept the
same for the entire study duration. Clinical and
instrumental evaluations and standardised photographic
re c o v e ry were performed at all visits
(T0, T8 and 16 weeks). In order to avoid possible
bias to the evaluations, during 3 hours before
the instrumental measurements the volunteers
could not smoke, drink coffee or alcohol. No
cosmetic product could be used on the skin test
a rea for 2 hours before the visit. All evaluations
w e re performed under standard enviro n m e n t a l
conditions (Te m p e r a t u re = 22+\-2°C; Relative
Humidity ≤ 60%). Before each visit the volunteers
were acclimatised under relax conditions
for at least 10-15 min.
Clinical evaluations were performed according
to the following visual scores:
Striae clinical score
– Grade 1: < 10 striae, length < 3 cm and thickness < 5 mm
– Grade 2: > 10 striae, length < 3 cm and thickness > 5 mm
– Grade 3: > 10 striae, length > 3 cm and thickness < 5 mm
– Grade 4: > 10 striae, length > 3 cm and thickness > 5 mm
Erythema, oedema, atrophy
– Absent 1
– Light 2
– Moderate 3
– Severe 4
Non invasive instrumental evaluations were the
following:
Electrical capacitance of skin (Hydration)
was measured by the instrument Corneometer
CM820 (Courage - Khazaka, Köln, Germany). To
reduce the variability of measurements, three
repeated measures on the same skin area were
performed and their adjusted mean was considered
as the real measure value.
Journal of Plastic Dermatology 2009; 5, 1
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