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Figure 3. Profilometry: average deepness of s t r e t c h m a r k s (Wt) (mm). Clinical and instrumental evaluation of the activity of a combined cosmetic treatment applied to stretchmarks Figure 1. Comparison of a treated site at T0, T8 and T16 (Vol. n. 19). and Ur (immediate elastic recovery) were all statistically significant at the end of the study. The Figure 2. Comparison of a treated site at T0, T8 and T16 (Vol. n. 24). following percentages of increase underline the activity of the treatment in improving skin elasticity and softness. Percentage of improvement v s baseline T8 T16 Ue 14.2% 24,4% Uf 18.8% 24,9% Uv 27,4% 25,9% Ur 3,8% 13,7% Skin electrical capacitance (hydration) Short term evaluation of electrical capacitance of treated skin, after 2 hours fro m the first application of each of the two pro d- Journal of Plastic Dermatology 2009; 5, 1 17
18 A. Sparavigna, B. Tenconi, I. De Ponti ucts gave an increment of hydration corresponding to 18% for D i s p a r i c ream and to 22% for P a r i c ream. Microrelief surface evaluation Although this evaluation, performed at T8, did not show a statistical significant variation of cutaneous surface microrelief regularity, a tendencial regularizing activity of the treatment on skin microrelief (+5%) was found. Self-evaluation questionnaire The overall activity of the treatment on striae was self perceived by the participating subjects in 72% of cases. C onclusions It is common clinical experience that topical treatment of stretchmarks is hardly successful especially for old lesions, which can be considered as scars caused by distension and rupture of dermal fibres. On the contrary, striae of recent onset may undergo spontaneous resolution. The combined treatment under study was able to provide a stimulus to fibroblasts in the dermis as well as an improved epidermal turnover. Instrumental measurements of striae deepness and skin elasticity, clinical evaluations and self evaluation questionnaire provided statistically significant results, especially for striae dating more than two years. L ectures Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, Bagchi M, Sen CK. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med 2002; 33:1089-96. Baliga MS, Katiyar SK. Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem Photobiol Sci 2006; 5:243-53. Lee AR. Enhancing dermal matrix regeneration and biomechanical properties of 2nd degree-burn wounds by EGFimpregnated collagen sponge dressing. Arch Pharm Res 2005; 28:1311-6. Carter K. Growth factors: the wound healing therapy of the f u t u re. Br J Community Nurs 2003; 8:S15-6, S18-9, S22-3. Bhora FY, Dunkin BJ, Batzri S, Aly HM, Bass BL, Sidawy AN, H a rmon JW. Effect of growth factors on cell proliferation and epithelialization in human skin. J Surg Res 2005; 59:236-44. Journal of Plastic Dermatology 2009; 5, 1 Thapa BR. Health factors in colostrum. Indian J Pediatr 2005; 72:849-52. Zhang YQ. Applications of natural silk protein sericin in biomaterials. Biotechnol Adv 2002; 20:91-100. Minoura N, Aiba S, Gotoh Y, Tsukada M, Imai Y. Attachment and growth of cultured fibroblast cells on silk protein matrices. J Biomed Mater Res 1995; 29:1215-21. Corcuff P, Chatenay F, Leveque JL. A fully automated system to study skin surface patterns. Int J Cosm Sci 1984, 6:167-186. De Rigal J, Leveque JL. In vivo measurement of the stratum c o rneum elasticity. Bioengineering and the skin 1985; 1:13-23. Elsner P., Berardesca E., Maibach H. Bioengineering of the skin: Water and the stratum corneum. CRC Press, Boca Raton, 1994. F e rn a y, Vo l t a i re. The World Medical Association “Wo r l d Medical Association Declaration of Helsinki”, Hong-Kong, 1 9 8 9 . Hoppe U, Sauermann G, Lunderstadt R. Quantitative analysis of the skin surface by means of digital signal processing. J Soc Cosmet Chem 1985; 36:105-123. ICH Harmonised Tripartite Guideline - Guideline for Good Clinical Practice. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, 1996. Mitts T, Jimenez F, Hinek A. Skin biopsy analysis reveals predisposition to stretchmark formation. Aesthetic Surgery Journal, 2005; 25:593-600. Prall JK. The effectiveness of cosmetic products in alleviating a range skin dryness conditions as determined by clinical and instrumental techniques. International Journal of Cosmetic Science 1986; 8:159-174. Sachs L. Applied statistics: a handbook of techniques. Heidelberg: Springer, 1981; 536-539. Salter DC et al. Skin mechanics measured in vivo using torsion: a new and accurate model more sensitive to age, sex and moisturizing treatment. Preprints 17t h I F S C C International Congress Yokohama 1992; 758-780. Setaro M., Sparavigna A. Morphological Evaluation of Skin Surface by Fourier’s Transform: A Study on the Phase and the Modulus” Preprints of 12th International Symposium on Bioengineering and the Skin, Boston 1998. Setaro M., Sparavigna A. Irregularity skin index (ISI): a tool to evaluate skin surface texture. Skin Research and Technology 2001; 7:159-163. Sparavigna A., Setaro M. Misurazione delle proprietà meccaniche della cute mediante metodi di torsione. In: “Diagnostica non invasiva in dermatologia”. A cura di Stefania Seidenari, EDRA. Medical Publishing & New Media, Milano, 1998, pp 323-328. Wilhelm KP, Elsner P, Berardesca E, Maibach HI. Bioengineering of the skin: Skin surface imaging and analysis. Boca Raton: CRC Press 1997.
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