instit.oncol.cluj-napoca- sectia hematologie - 2012
instit.oncol.cluj-napoca- sectia hematologie - 2012
instit.oncol.cluj-napoca- sectia hematologie - 2012
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d. In general, daca pacientii nu raspund la Epo, se intrerupe tratamentul dupa 8-12<br />
saptamani<br />
e. Raspunsul la Epo se defineste:<br />
- Cresterea Hgb>1g fata de valoarea intiala<br />
- Independenta de transfuzii<br />
f. Administrarea Epo la Hgb>11-12g/dl este contraindicata<br />
4. G-CSF<br />
a. Se indica rareori, in caz de neutropenii severe (1000µg/l<br />
- Biopsie hepatica cu evidentierea supraincarcarii cu fier<br />
- RMN hepatic – aspect sugestiv la T2*<br />
b. Preparate:<br />
- Deferioxamina (Desferal) : 25/60mg/kg, de preferinta perfuzie lenta s.c.<br />
8-10h/zi<br />
- Deferasirox (Exjade) : 20-40 mg/kg/zi p.o. intr-o singura priza,<br />
dimineata, a jeun<br />
c. Dozele de chelatori se pot scadea la Feritina
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