instit.oncol.cluj-napoca- sectia hematologie - 2012
instit.oncol.cluj-napoca- sectia hematologie - 2012
instit.oncol.cluj-napoca- sectia hematologie - 2012
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Citozinarabinozid 2 X 200mg/m2, IV, zilele -5,-4,-3,-2<br />
Melfalan 140mg/m2, IV, ziua -1<br />
Autogrefa de celule stem - ziua 0<br />
10. Schema PEP-C (tratament metronomic)<br />
Prednison 20mg/zi, zilnic sau 5 zile/saptamana<br />
Etopozid 50mg/zi, zilnic sau 5 zile/saptamana<br />
Procarbazina 50mg/zi zilnic sau 5 zile/saptamana<br />
Ciclofosfamida 50mg/zi sau 5 zile/sapt<br />
* Este ideal ca schemele de chimioterapie sa fie facute la timp, indiferent de toxicitatea<br />
hematologica. In caz de toxicitate hematologica, este mai bine sa se asigure masuri suportive<br />
(transfuzii, G-CSF, antibiotice) decat sa se amane administrarile de citostatice.<br />
BIBLIOGRAFIE<br />
1. Williams Hematology, 8 th Edition. McGraw Hill, 2010<br />
2. Petrov L, Cucuianu A, Bojan A, Urian L. Hematologie Clinica. Casa Cartii de Stiinta, Cluj-<br />
Napoca, 2009.<br />
3. Societe Francaise d’Hematologie. Referentiel 2009<br />
4. Kuruvilla J, Keating A, Crump M. How I treat relapsed and refractory Hodgkin’s<br />
lymphoma. Blood 2011; 117: 4208-4217<br />
5. Maucort-Boulch D, Djeridane M, Roy B, Colonna P, Andrieu JM. Predictive and<br />
discriminating three risk group prognostic scoring system for staging Hodgkin lymphoma.<br />
Cancer 2007;109:256-264.<br />
6. Fermé C, Eghbali H, Meerwaldt JH, et al. Chemotherapy plus involved-field radiation in<br />
early-stage Hodgkin's disease. N Engl J Med 2007;357:1916-27.<br />
7. Behringer K, Diehl V. Twenty-five years clinical trials of the German Hodgkin Study<br />
Group (GHSG). Eur J Haematol 2005:75:21-25. \<br />
8. Engert A, Eichenauer DA, Dreyling M. Hodgkin’s Lymphoma. ESMO clinical<br />
reccomendations for diagnosis and follow-up. Annals of Oncology 2009, 20, Suppl 4, 108-<br />
109<br />
9. NCCN Guidelines Version 2.<strong>2012</strong>. Hodgkin’s Lymphoma<br />
http://www.nccn.org/professionals/physician_gls/pdf/hodgkins.pdf